AC MF_00851; DC Protein; auto TR HAMAP; MF_00851; -; 1; level=0 XX Names: Leader_SpeFL XX ID SPEFL DE RecName: Full=Leader peptide SpeFL; DE AltName: Full=Arrest peptide SpeFL; GN Name=speFL; XX CC -!- FUNCTION: A small protein (arrest peptide) encoded upstream of CC inducible ornithine carboxylase gene (speF) that controls expression of CC downstream genes (usually speF and potE) by transcriptional and CC translational attenuation. CC -!- SUBUNIT: Binds ornithine in stalled 70S ribosomes, blocking the upper CC two-thirds of the exit tunnel. Contacts 23S rRNA and ribosomal proteins CC L4 and L22. CC -!- INDUCTION: Induced by ornithine, repressed by putrescine. Part of the CC speFL-speF-potE operon. CC -!- SIMILARITY: Belongs to the speF operon leader peptide family. XX DR Pfam; PF10940; DUF2618; 0-1; trigger=no XX KW Leader peptide KW RNA-binding KW Transcription KW Transcription regulation KW Translation regulation KW rRNA-binding XX GO GO:0006448; P:regulation of translational elongation GO GO:0031556; P:transcriptional attenuation by ribosome XX FT From: SPEFL_ECOLI (P0DTV7) FT MOTIF 10..16 FT /note="Ornithine recognition loop" FT Condition: H-I-R-R-x-x-H FT BINDING 13 FT /ligand="L-ornithine" FT /ligand_id="ChEBI:CHEBI:46911" FT Condition: R XX Size: 34-64; Related: None; Template: P0DTV7; P0DTV8; Scope: Bacteria; Gammaproteobacteria Fusion: Nter: None Cter: None Duplicate: None Plasmid: None Comments: None XX # Revision 1.5 2022/11/19 //