AC   MF_00853;
DC   Protein; auto
TR   HAMAP; MF_00853; -; 1; level=0
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Names: HemG
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ID   HEMG
DE   RecName: Full=Protoporphyrinogen IX dehydrogenase [quinone];
DE            EC=1.3.5.3;
DE   AltName: Full=Protoporphyrinogen IX dehydrogenase [menaquinone];
DE   AltName: Full=Protoporphyrinogen IX dehydrogenase [ubiquinone];
DE   AltName: Full=Protoporphyrinogen oxidase;
DE            Short=PPO;
GN   Name=hemG;
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CC   -!- FUNCTION: Catalyzes the 6-electron oxidation of protoporphyrinogen IX
CC       to form protoporphyrin IX; under anaerobic conditions uses menaquinone
CC       as an electron acceptor, under aerobic conditions uses ubiquinone as an
CC       electron acceptor.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 a quinone + protoporphyrinogen IX = 3 a quinol +
CC         protoporphyrin IX; Xref=Rhea:RHEA:65032, ChEBI:CHEBI:24646,
CC         ChEBI:CHEBI:57306, ChEBI:CHEBI:57307, ChEBI:CHEBI:132124; EC=1.3.5.3;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol +
CC         protoporphyrin IX; Xref=Rhea:RHEA:27409, Rhea:RHEA-COMP:9537,
CC         Rhea:RHEA-COMP:9539, ChEBI:CHEBI:16374, ChEBI:CHEBI:18151,
CC         ChEBI:CHEBI:57306, ChEBI:CHEBI:57307; EC=1.3.5.3;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol +
CC         protoporphyrin IX; Xref=Rhea:RHEA:63936, Rhea:RHEA-COMP:9565,
CC         Rhea:RHEA-COMP:9566, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57306, ChEBI:CHEBI:57307;
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210;
CC       Note=Binds 1 FMN non-covalently per subunit.;
CC   -!- PATHWAY: Porphyrin-containing compound metabolism; protoporphyrin-IX
CC       biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the HemG family.
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DR   PROSITE; PS00201; FLAVODOXIN; 0-1; trigger=no
DR   PROSITE; PS50902; FLAVODOXIN_LIKE; 0-1; trigger=yes
DR   Pfam; PF12724; Flavodoxin_5; 1; trigger=no
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case <Property:Membrane=2>
KW   Cell inner membrane
else case not defined <Property:Membrane> or <Property:Membrane=1>
KW   Cell membrane
end case
KW   FMN
KW   Flavoprotein
KW   Nucleotide-binding
KW   Oxidoreductase
KW   Porphyrin biosynthesis
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GO   GO:0006782; P:protoporphyrinogen IX biosynthetic process
GO   GO:0070819; F:menaquinone-dependent protoporphyrinogen oxidase activity
GO   GO:0010181; F:FMN binding
GO   GO:0006783; P:heme biosynthetic process
GO   GO:0005886; C:plasma membrane
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FT   None
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Size: 163-241;
Related: None;
Template: P0ACB4; Q4QIU7;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.3 2020/08/25
//