AC   MF_00868;
DC   Protein; auto
TR   HAMAP; MF_00868; -; 1; level=0
XX
Names: Cds1
XX
ID   CDS1
DE   RecName: Full=L-cysteine desulfhydrase Cds1;
DE            EC=4.4.1.1;
GN   Name=cds1;
XX
case <OC:Actinomycetota>
CC   -!- FUNCTION: A cysteine desulfhydrase that generates hydrogen sulfide,
CC       H(2)S. The H(2)S produced by this enzyme modulates the balance between
CC       respiration and glycolysis, and contributes to redox homeostasis.
CC       Probably eliminates toxic levels of Cys (which can induce oxidative
CC       stress).
else
CC   -!- FUNCTION: A cysteine desulfhydrase that generates hydrogen sulfide,
CC       H(2)S. The H(2)S produced by this enzyme may modulate central
CC       metabolism.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-cysteine = H(+) + hydrogen sulfide + NH4(+) +
CC         pyruvate; Xref=Rhea:RHEA:24931, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:29919,
CC         ChEBI:CHEBI:35235; EC=4.4.1.1;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:24932;
case <FT:1>
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
end case
CC   -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC       synthase family. Cds1 subfamily.
XX
DR   Pfam; PF00291; PALP; 1; trigger=no
XX
KW   Cytoplasm
KW   Lyase
case <FT:1>
KW   Pyridoxal phosphate
end case
XX
GO   GO:0005737; C:cytoplasm
GO   GO:0030170; F:pyridoxal phosphate binding
GO   GO:0019450; P:L-cysteine catabolic process to pyruvate
XX
FT   From: CDS1_MYCTU (O69652)
FT   MOD_RES         67
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
XX
Size: 340-440;
Related: None;
Template: O69652; A5U908;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.4 2023/01/13
//