AC   MF_00869;
DC   Protein; auto
TR   HAMAP; MF_00869; -; 1; level=0
XX
Names: Fusexin-1
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ID   FSX1
DE   RecName: Full=Fusexin 1;
DE            Short=Fsx1;
GN   Name=fsx1;
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CC   -!- FUNCTION: Exhibits fusogenic activity, mediates cell-cell fusion when
CC       present in both cells (bilateral fusion).
CC   -!- SUBUNIT: Homotrimer stabilized by interdomain contacts and numerous
CC       Ca(2+) and Na(+) ions.
CC   -!- SUBCELLULAR LOCATION: Cell surface. Cell membrane; multi-pass membrane
CC       protein.
CC   -!- DOMAIN: The extracellular N-terminus has 4 domains; the first 3 are
CC       structurally similar to fusogens from plants, C.elegans and viruses,
CC       while the fourth domain is unique to archaea. Domains I and II are
CC       discontinuous. The fusion loop in domain II is stabilized by a Ca(2+)
CC       ion so that it protrudes from the molecule.
CC   -!- SIMILARITY: Belongs to the HAP2/GCS1 family. Fusexin 1 subfamily.
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DR   Pfam; PF10699; HAP2-GCS1; 0-1; trigger=no
DR   General; Signal; -; 0-1; trigger=yes
DR   General; Transmembrane; -; 0-5; trigger=yes
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KW   Calcium
KW   Cell membrane
case <FT:2> or <FT:3> or <FT:4> or <FT:5>
KW   Disulfide bond
end case
KW   Membrane
KW   Metal-binding
case <Feature:Signal>
KW   Signal
end case
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0005886; C:plasma membrane
GO   GO:0045026; P:plasma membrane fusion
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FT   From: FSX1_UNCAX (C0HM55)
FT   REGION          143..148
FT                   /note="Fusion loop"
FT   DISULFID        125..155
FT   Optional; Condition: C-x*-C
FT   DISULFID        389..432
FT   Optional; Condition: C-x*-C
FT   DISULFID        457..477
FT   Optional; Condition: C-x*-C
FT   DISULFID        490..506
FT   Optional; Condition: C-x*-C
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Size: 536-764;
Related: None;
Template: C0HM55;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.2 2023/02/07
//