AC   MF_00870;
DC   Protein; auto
TR   HAMAP; MF_00870; -; 1; level=0
XX
Names: FttA
XX
ID   FTTA
DE   RecName: Full=Transcription termination factor FttA;
DE            EC=3.1.-.-;
GN   Name=fttA;
XX
CC   -!- FUNCTION: Terminates transcription on the whole genome. Termination is
CC       linked to FttA-mediated RNA cleavage and does not require NTP
CC       hydrolysis. Cleaves endonucleolytically at the RNA exit channel of RNA
CC       polymerase (RNAP); the 5'-3' exonuclease activity of this protein
CC       degrades the nascent RNA released from RNAP.
case <FTGroup:1> and <FTGroup:2>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 2 Zn(2+) ions, which are required for nuclease activity.
end case
CC   -!- SUBUNIT: Homodimer. Interacts with RNA polymerase (RNAP), interacts
CC       with the Spt4-Spt5 complex.
CC   -!- SIMILARITY: Belongs to the metallo-beta-lactamase superfamily. RNA-
CC       metabolizing metallo-beta-lactamase-like family. FttA subfamily.
XX
DR   PROSITE; PS50084; KH_TYPE_1; 0-1; trigger=no
DR   Pfam; PF00753; Lactamase_B; 0-1; trigger=no
DR   Pfam; PF07521; RMMBL; 1; trigger=no
DR   Pfam; PF07650; KH_2; 0-1; trigger=no
DR   Pfam; PF10996; Beta-Casp; 1; trigger=no
DR   Pfam; PF16661; Lactamase_B_6; 0-1; trigger=no
DR   Pfam; PF17214; KH_7; 1; trigger=no
DR   NCBIfam; TIGR03675; arCOG00543; 1; trigger=no
XX
KW   DNA-binding
KW   Endonuclease
KW   Exonuclease
KW   Hydrolase
KW   Nuclease
KW   RNA-binding
KW   Transcription regulation
KW   Transcription termination
case <FTGroup:1> or <FTGroup:2>
KW   Zinc
KW   Metal-binding
end case
XX
GO   GO:0006353; P:DNA-templated transcription termination
GO   GO:0003723; F:RNA binding
GO   GO:0004521; F:RNA endonuclease activity
GO   GO:0004532; F:RNA exonuclease activity
case <FTGroup:1> or <FTGroup:2>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: FTTA_METTH (O27271)
FT   REGION          3..70
FT                   /note="KHa"
FT   REGION          71..138
FT                   /note="KHb"
FT   REGION          179..383
FT                   /note="Metallo-beta-lactamase N-terminus"
FT   REGION          384..577
FT                   /note="Beta-Casp"
FT   REGION          578..636
FT                   /note="Metallo-beta-lactamase C-terminus"
FT   BINDING         242
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Group: 1; Condition: H
FT   BINDING         244
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Group: 1; Condition: H
FT   BINDING         246
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Group: 2; Condition: D
FT   BINDING         247
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Group: 2; Condition: H
FT   BINDING         329
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Group: 1; Condition: H
FT   BINDING         352
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT   Group: 1; Condition: D
FT   BINDING         352
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Group: 2; Condition: D
FT   BINDING         603
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT   Group: 2; Condition: H
XX
Size: 634-651;
Related: None;
Template: Q5JH24; Q6LZD5; O27271; Q8PZ03; Q9V0P0;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
# Revision 1.2 2024/03/04
//