AC   MF_00871;
DC   Protein; auto
TR   HAMAP; MF_00871; -; 1; level=0
XX
Names: RqcP
XX
ID   RQCP
DE   RecName: Full=RQC P-site tRNA stabilizing factor;
DE            Short=RqcP;
DE   AltName: Full=Ribosome-associated protein quality control protein P;
GN   Name=rqcP;
XX
CC   -!- FUNCTION: Key component of the ribosome quality control system (RQC), a
CC       ribosome-associated complex that mediates the extraction of
CC       incompletely synthesized nascent chains from stalled ribosomes and
CC       their subsequent degradation. RqcH recruits Ala-charged tRNA, and with
CC       RqcP directs the elongation of stalled nascent chains on 50S ribosomal
CC       subunits, leading to non-templated C-terminal alanine extensions (Ala
CC       tail). The Ala tail promotes nascent chain degradation. RqcP is
CC       associated with the translocation-like movement of the peptidyl-tRNA
CC       from the A-site into the P-site.
CC   -!- SUBUNIT: Associates with stalled 50S ribosomal subunits. Binds to RqcH,
CC       23S rRNA and the P-site tRNA. Does not require RqcH for association
CC       with 50S subunits.
CC   -!- SIMILARITY: Belongs to the RqcP family.
XX
DR   PROSITE; PS50889; S4; 1; trigger=yes
DR   Pfam; PF01479; S4; 1; trigger=no
DR   PIRSF; PIRSF038881; RNAbp_HP1423; 1; trigger=no
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KW   Protein biosynthesis
KW   RNA-binding
KW   rRNA-binding
KW   tRNA-binding
XX
GO   GO:0019843; F:rRNA binding
GO   GO:0000049; F:tRNA binding
GO   GO:0043023; F:ribosomal large subunit binding
GO   GO:0072344; P:rescue of stalled ribosome
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FT   None
XX
Size: 79-103;
Related: None;
Template: P37557;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 3
# Last updated date: 2024-09-04
# Created date: 2024-09-03
//