AC   MF_00905;
DC   Protein; auto
TR   HAMAP; MF_00905; -; 1; level=0
XX
Names: cAMP_phosphodiest_CpdA
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ID   CPDA
DE   RecName: Full=3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA;
DE            Short=3',5'-cyclic AMP phosphodiesterase;
DE            Short=cAMP phosphodiesterase;
DE            EC=3.1.4.53;
GN   Name=cpdA;
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CC   -!- FUNCTION: Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role
CC       in modulating the intracellular concentration of cAMP, thereby
CC       influencing cAMP-dependent processes.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3',5'-cyclic AMP + H2O = AMP + H(+); Xref=Rhea:RHEA:25277,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:58165,
CC         ChEBI:CHEBI:456215; EC=3.1.4.53;
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC       Note=Binds 2 Fe(2+) ions per subunit.;
CC   -!- SIMILARITY: Belongs to the cAMP phosphodiesterase class-III family.
XX
DR   Pfam; PF00149; Metallophos; 1; trigger=no
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KW   cAMP
KW   Hydrolase
KW   Iron
KW   Metal-binding
KW   Nucleotide-binding
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GO   GO:0004115; F:3',5'-cyclic-AMP phosphodiesterase activity
GO   GO:0046872; F:metal ion binding
GO   GO:0000166; F:nucleotide binding
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FT   From: CPDA_MYCTU (P9WP65)
FT   NP_BIND         97..98
FT                   /note="3',5'-cAMP"
FT   Condition: N-H
FT   METAL           21
FT                   /note="Iron 1"
FT   Condition: D
FT   METAL           23
FT                   /note="Iron 1"
FT   Condition: H
FT   METAL           63
FT                   /note="Iron 1"
FT   Condition: D
FT   METAL           63
FT                   /note="Iron 2"
FT   Condition: D
FT   METAL           97
FT                   /note="Iron 2"
FT   Condition: N
FT   METAL           169
FT                   /note="Iron 2"
FT   Condition: H
FT   METAL           207
FT                   /note="Iron 2"
FT   Condition: H
FT   METAL           209
FT                   /note="Iron 1"
FT   Condition: H
FT   BINDING         23
FT                   /note="3',5'-cAMP"
FT   Condition: H
FT   BINDING         63
FT                   /note="3',5'-cAMP"
FT   Condition: D
FT   BINDING         209
FT                   /note="3',5'-cAMP"
FT   Condition: H
XX
Size: 233-340;
Related: None;
Template: P9WP65; P0AEW4; D4P095; Q8YLG0; P44685;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in COXBU
Comments: None
XX
# Revision 1.9 2021/03/02
//