AC   MF_00908;
DC   Protein; auto
TR   HAMAP; MF_00908; -; 1; level=0
XX
Names: SeqA
XX
ID   SEQA
DE   RecName: Full=Negative modulator of initiation of replication;
GN   Name=seqA;
XX
CC   -!- FUNCTION: Negative regulator of replication initiation, which
CC       contributes to regulation of DNA replication and ensures that
CC       replication initiation occurs exactly once per chromosome per cell
CC       cycle. Binds to pairs of hemimethylated GATC sequences in the oriC
CC       region, thus preventing assembly of replication proteins and re-
CC       initiation at newly replicated origins. Repression is relieved when the
CC       region becomes fully methylated.
CC   -!- SUBUNIT: Homodimer. Polymerizes to form helical filaments.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the SeqA family.
XX
DR   Pfam; PF03925; SeqA; 1; trigger=no
XX
KW   Cytoplasm
KW   DNA replication inhibitor
KW   DNA-binding
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GO   GO:0003677; F:DNA binding
GO   GO:0032297; P:negative regulation of DNA-templated DNA replication initiation
GO   GO:0005737; C:cytoplasm
XX
FT   From: SEQA_ECOLI (P0AFY8)
FT   REGION          87..88
FT                   /note="Interaction with DNA"
FT   Optional; Condition: A-V
FT   REGION          116..120
FT                   /note="Interaction with DNA"
FT   Optional; Condition: R-T-R-[VIL]-Y
FT   REGION          150..156
FT                   /note="Interaction with DNA"
FT   Optional; Condition: N-[TS]-N-[TS]-G-[RK]-K
XX
Size: 149-253;
Related: None;
Template: P0AFY8;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in SHEB5
Comments: None
XX
# Revision 1.4 2022/05/03
//