AC   MF_00913;
DC   Protein; auto
TR   HAMAP; MF_00913; -; 1; level=0
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Names: PGT_FtsW_proteobact
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ID   FTSW
DE   RecName: Full=Probable peptidoglycan glycosyltransferase FtsW;
DE            Short=PGT;
DE            EC=2.4.1.129;
DE   AltName: Full=Cell division protein FtsW;
DE   AltName: Full=Cell wall polymerase;
DE   AltName: Full=Peptidoglycan polymerase;
DE            Short=PG polymerase;
GN   Name=ftsW;
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CC   -!- FUNCTION: Peptidoglycan polymerase that is essential for cell division.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC         Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC         (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC         cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC         D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC         diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC         Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC         ChEBI:CHEBI:78435; EC=2.4.1.129;
CC   -!- PATHWAY: Cell wall biogenesis; peptidoglycan biosynthesis.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC       Note=Localizes to the division septum.
CC   -!- SIMILARITY: Belongs to the SEDS family. FtsW subfamily.
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DR   PROSITE; PS00428; FTSW_RODA_SPOVE; 1; trigger=no
DR   Pfam; PF01098; FTSW_RODA_SPOVE; 1; trigger=no
DR   NCBIfam; TIGR02614; FtsW; 1; trigger=no
DR   General; Transmembrane; -; 8-10; trigger=yes
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KW   Cell cycle
KW   Cell division
KW   Cell inner membrane
KW   Cell membrane
KW   Cell shape
KW   Cell wall biogenesis/degradation
KW   Glycosyltransferase
KW   Membrane
KW   Peptidoglycan synthesis
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
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GO   GO:0008955; F:peptidoglycan glycosyltransferase activity
GO   GO:0043093; P:FtsZ-dependent cytokinesis
GO   GO:0009252; P:peptidoglycan biosynthetic process
GO   GO:0032153; C:cell division site
GO   GO:0005886; C:plasma membrane
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FT   None
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Size: 353-524;
Related: None;
Template: P0ABG4; P0ABG7;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: The HAMAP profile and rule are restricted to Betaproteobacteria and
 Gammaproteobacteria to avoid wrong matches and wrong annotation in UniProt/TrEMBL.
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# Revision 1.15 2023/06/01
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