AC   MF_00920;
DC   Protein; auto
TR   HAMAP; MF_00920; -; 1; level=0
XX
Names: FtsY
XX
ID   FTSY
DE   RecName: Full=Signal recognition particle receptor FtsY;
DE            Short=SRP receptor;
DE            EC=3.6.5.4;
GN   Name=ftsY;
XX
case <OC:Pseudomonadota>
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Acts as a receptor for the
CC       complex formed by the signal recognition particle (SRP) and the
CC       ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the
CC       transfer of the RNC complex to the Sec translocase for insertion into
CC       the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the
CC       dissociation of the SRP-FtsY complex into the individual components.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.4;
CC   -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC       system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein
CC       composed of Ffh and a 4.5S RNA molecule.
else
CC   -!- FUNCTION: Involved in targeting and insertion of nascent membrane
CC       proteins into the cytoplasmic membrane. Acts as a receptor for the
CC       complex formed by the signal recognition particle (SRP) and the
CC       ribosome-nascent chain (RNC).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.4;
CC   -!- SUBUNIT: Part of the signal recognition particle protein translocation
CC       system, which is composed of SRP and FtsY.
end case
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Cytoplasm.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Cytoplasm.
end case
case <OC:Escherichia> or <OC:Shigella> or <OC:Salmonella>
CC   -!- DOMAIN: Contains an acidic N-terminal A domain, a central N domain and
CC       a C-terminal GTPase G domain that can bind and hydrolyze GTP. Contains
CC       at least two lipid-binding sites. The first site contains the first 14
CC       amino acids (helix 1) and the second binding site is an amphipathic
CC       alpha-helix located at the interface between the A- and the N-domain
CC       (helix 2).
end case
CC   -!- SIMILARITY: Belongs to the GTP-binding SRP family. FtsY subfamily.
XX
DR   PROSITE; PS00300; SRP54; 1; trigger=no
DR   Pfam; PF00448; SRP54; 1; trigger=no
DR   Pfam; PF02881; SRP54_N; 1; trigger=no
DR   NCBIfam; TIGR00064; FtsY; 1; trigger=no
XX
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Cytoplasm
KW   GTP-binding
KW   Hydrolase
KW   Membrane
KW   Nucleotide-binding
KW   Receptor
XX
GO   GO:0005525; F:GTP binding
GO   GO:0003924; F:GTPase activity
GO   GO:0006612; P:protein targeting to membrane
GO   GO:0005737; C:cytoplasm
GO   GO:0005886; C:plasma membrane
XX
FT   From: FTSY_ECOLI (P10121)
FT   BINDING         300..307
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Optional; Condition: G-x-N-G-x-G-K-T
FT   BINDING         382..386
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Optional; Condition: D-[TS]-[AS]-G-R
FT   BINDING         446..449
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT   Optional; Condition: [TS]-K-x-[DE]
XX
Size: 288-504;
Related: None;
Template: P10121;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.10 2023/06/01
//