AC   MF_00935;
DC   Protein; auto
TR   HAMAP; MF_00935; -; 1; level=0
XX
Names: AlaDH_arch
XX
ID   ALADH
case <OC:Archaea>
DE   RecName: Full=Alanine dehydrogenase;
DE            Short=AlaDH;
DE            EC=1.4.1.1;
GN   Name=ala;
else case <OC:Bacteria>
DE   RecName: Full=Putative alanine dehydrogenase;
DE            Short=AlaDH;
DE            EC=1.4.1.1;
end case
XX
CC   -!- FUNCTION: Catalyzes the NAD(+)-dependent oxidative deamination of L-
CC       alanine to pyruvate, and the reverse reaction, the reductive amination
CC       of pyruvate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate;
CC         Xref=Rhea:RHEA:18405, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:28938, ChEBI:CHEBI:57540,
CC         ChEBI:CHEBI:57945, ChEBI:CHEBI:57972; EC=1.4.1.1;
CC   -!- SIMILARITY: Belongs to the ornithine cyclodeaminase/mu-crystallin
CC       family. Archaeal alanine dehydrogenase subfamily.
XX
DR   Pfam; PF02423; OCD_Mu_crystall; 1; trigger=no
DR   NCBIfam; TIGR02371; ala_DH_arch; 1; trigger=no
DR   PIRSF; PIRSF001439; CryM; 1; trigger=no
XX
KW   NAD
KW   Nucleotide-binding
KW   Oxidoreductase
XX
GO   GO:0000286; F:alanine dehydrogenase activity
GO   GO:0051287; F:NAD binding
GO   GO:0006522; P:alanine metabolic process
XX
FT   From: ALADH_ARCFU (O28608)
FT   BINDING         135..136
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: x-Q
FT   BINDING         157..159
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Optional; Condition: [DN]-x-[RKH]
FT   BINDING         217..219
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: G-x-D
FT   ACT_SITE        65
FT                   /note="Proton donor/acceptor"
FT   Condition: K
FT   BINDING         108
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: R
FT   BINDING         223
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: K
FT   BINDING         290
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT   Condition: S
XX
Size: 291-359;
Related: None;
Template: O28608;
Scope:
 Archaea
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.8 2023/06/01
//