AC   MF_00936;
DC   Protein; auto
TR   HAMAP; MF_00936; -; 1; level=0
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Names: ParC_type1
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ID   PARC
DE   RecName: Full=DNA topoisomerase 4 subunit A;
DE            EC=5.6.2.2;
DE   AltName: Full=Topoisomerase IV subunit A;
GN   Name=parC;
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CC   -!- FUNCTION: Topoisomerase IV is essential for chromosome segregation. It
CC       relaxes supercoiled DNA. Performs the decatenation events required
CC       during the replication of a circular DNA molecule.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2;
CC   -!- SUBUNIT: Heterotetramer composed of ParC and ParE.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
CC   -!- SIMILARITY: Belongs to the type II topoisomerase GyrA/ParC subunit
CC       family. ParC type 1 subfamily.
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DR   Pfam; PF03989; DNA_gyraseA_C; 2-3; trigger=no
DR   Pfam; PF00521; DNA_topoisoIV; 1; trigger=no
DR   NCBIfam; TIGR01062; parC_Gneg; 1; trigger=no
DR   PROSITE; PS52040; TOPO_IIA; 1; trigger=yes
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KW   Cell membrane
KW   DNA-binding
KW   Isomerase
KW   Membrane
KW   Topoisomerase
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GO   GO:0003677; F:DNA binding
GO   GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO   GO:0007059; P:chromosome segregation
GO   GO:0006265; P:DNA topological change
GO   GO:0019897; C:extrinsic component of plasma membrane
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FT   From: PARC_ECOLI (P0AFI2)
FT   ACT_SITE        120
FT                   /note="O-(5'-phospho-DNA)-tyrosine intermediate"
FT   Condition: Y
FT   SITE            39
FT                   /note="Interaction with DNA"
FT   Optional; Condition: K
FT   SITE            75
FT                   /note="Interaction with DNA"
FT   Optional; Condition: H
FT   SITE            77
FT                   /note="Interaction with DNA"
FT   Optional; Condition: H
FT   SITE            119
FT                   /note="Transition state stabilizer"
FT   Condition: R
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Size: 710-820;
Related: None;
Template: P0AFI2; P72525;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: See MF_00937 for ParC type 2 subfamily.
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# Revision 1.14 2023/10/10
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