AC   MF_00938;
DC   Protein; auto
TR   HAMAP; MF_00938; -; 1; level=0
XX
Names: ParE_type1
XX
ID   PARE
DE   RecName: Full=DNA topoisomerase 4 subunit B;
DE            EC=5.6.2.2;
DE   AltName: Full=Topoisomerase IV subunit B;
GN   Name=parE;
XX
CC   -!- FUNCTION: Topoisomerase IV is essential for chromosome segregation. It
CC       relaxes supercoiled DNA. Performs the decatenation events required
CC       during the replication of a circular DNA molecule.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP-dependent breakage, passage and rejoining of double-
CC         stranded DNA.; EC=5.6.2.2;
CC   -!- SUBUNIT: Heterotetramer composed of ParC and ParE.
CC   -!- SIMILARITY: Belongs to the type II topoisomerase family. ParE type 1
CC       subfamily.
XX
DR   PROSITE; PS00177; TOPOISOMERASE_II; 1; trigger=no
DR   PROSITE; PS50880; TOPRIM; 1; trigger=yes
DR   Pfam; PF00204; DNA_gyraseB; 1; trigger=no
DR   Pfam; PF00986; DNA_gyraseB_C; 1; trigger=no
DR   Pfam; PF02518; HATPase_c; 1; trigger=no
DR   Pfam; PF01751; Toprim; 1; trigger=no
DR   PRINTS; PR00418; TPI2FAMILY; 1; trigger=no
DR   NCBIfam; TIGR01055; parE_Gneg; 1; trigger=no
XX
KW   ATP-binding
KW   DNA-binding
KW   Isomerase
KW   Nucleotide-binding
KW   Topoisomerase
XX
GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO   GO:0007059; P:chromosome segregation
GO   GO:0006265; P:DNA topological change
XX
FT   From: PARE_ECOLI (P20083)
FT   BINDING         110..116
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Condition: G-L-[HN]-G-V-G-x
FT   BINDING         5
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: Y
FT   BINDING         42
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: N
FT   BINDING         69
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: D
FT   BINDING         334
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT   Optional; Condition: K
FT   SITE            446
FT                   /note="Interaction with DNA"
FT   Optional; Condition: N
FT   SITE            497
FT                   /note="Interaction with DNA"
FT   Optional; Condition: H
FT   SITE            615
FT                   /note="Interaction with DNA"
FT   Optional; Condition: R
XX
Size: 600-750;
Related: None;
Template: P20083; Q59961;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: See MF_00939 for ParE type 2 subfamily.
XX
# Revision 1.12 2023/06/01
//