AC   MF_00942;
DC   Protein; auto
TR   HAMAP; MF_00942; -; 1; level=0
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Names: Nth
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ID   END3
DE   RecName: Full=Endonuclease III;
DE            EC=4.2.99.18;
DE   AltName: Full=DNA-(apurinic or apyrimidinic site) lyase;
GN   Name=nth;
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CC   -!- FUNCTION: DNA repair enzyme that has both DNA N-glycosylase activity
CC       and AP-lyase activity. The DNA N-glycosylase activity releases various
CC       damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving
CC       an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the
CC       phosphodiester bond 3' to the AP site by a beta-elimination, leaving a
CC       3'-terminal unsaturated sugar and a product with a terminal 5'-
CC       phosphate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-
CC         deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-
CC         dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-
CC         deoxyribonucleoside-DNA + H(+); Xref=Rhea:RHEA:66592, Rhea:RHEA-
CC         COMP:13180, Rhea:RHEA-COMP:16897, Rhea:RHEA-COMP:17067,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:136412, ChEBI:CHEBI:157695,
CC         ChEBI:CHEBI:167181; EC=4.2.99.18;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster.;
CC   -!- SIMILARITY: Belongs to the Nth/MutY family.
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DR   PROSITE; PS00764; ENDONUCLEASE_III_1; 1; trigger=no
DR   PROSITE; PS01155; ENDONUCLEASE_III_2; 1; trigger=no
DR   Pfam; PF10576; EndIII_4Fe-2S; 1; trigger=no
DR   Pfam; PF00633; HHH; 1; trigger=yes
DR   Pfam; PF00730; HhH-GPD; 1; trigger=no
DR   NCBIfam; TIGR01083; nth; 1; trigger=no
DR   PIRSF; PIRSF001435; Nth; 1; trigger=no
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KW   DNA-binding
KW   DNA damage
KW   DNA repair
KW   Glycosidase
KW   Hydrolase
KW   Lyase
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
end case
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GO   GO:0019104; F:DNA N-glycosylase activity
GO   GO:0003906; F:DNA-(apurinic or apyrimidinic site) endonuclease activity
GO   GO:0003677; F:DNA binding
case <FTGroup:1>
GO   GO:0051539; F:4 iron, 4 sulfur cluster binding
end case
GO   GO:0006281; P:DNA repair
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FT   From: END3_ECOLI (P0AB83)
FT   BINDING         187
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         194
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         197
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         203
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
XX
Size: 177-390;
Related: None;
Template: P0AB83; P9WQ11;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.15 2024/01/30
//