AC   MF_00955;
DC   Protein; auto
TR   HAMAP; MF_00955; -; 1; level=0
XX
Names: GDP_Man_dehydratase
XX
ID   GM4D
DE   RecName: Full=GDP-mannose 4,6-dehydratase;
DE            EC=4.2.1.47;
DE   AltName: Full=GDP-D-mannose dehydratase;
GN   Name=gmd;
XX
CC   -!- FUNCTION: Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-
CC       deoxy-D-mannose.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O;
CC         Xref=Rhea:RHEA:23820, ChEBI:CHEBI:15377, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:57964; EC=4.2.1.47;
CC   -!- COFACTOR:
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. GDP-mannose 4,6-dehydratase subfamily.
XX
DR   Pfam; PF01370; Epimerase; 1; trigger=no
DR   NCBIfam; TIGR01472; gmd; 1; trigger=no
XX
KW   Lyase
KW   NADP
XX
GO   GO:0008446; F:GDP-mannose 4,6-dehydratase activity
GO   GO:0070401; F:NADP+ binding
XX
FT   From: GMD2_ARATH (P0AC88)
FT   BINDING         35..40
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: G-x-x-G-Q-D
FT   BINDING         91..92
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: D-[LMIV]
FT   BINDING         113..117
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: L-x-[AG]-x-[ST]
FT   ACT_SITE        162
FT   Condition: [TS]
FT   ACT_SITE        164
FT                   /note="Nucleophile"
FT   Condition: E
FT   ACT_SITE        185
FT                   /note="Nucleophile"
FT   Condition: Y
FT   BINDING         128
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: Y
FT   BINDING         189
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: K
FT   BINDING         215
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: H
FT   BINDING         220
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: R
XX
Size: 300-430;
Related: None;
Template: P0AC88; Q51366;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in RHIFH, SINFN
Comments: None
XX
# Revision 1.12 2023/06/01
//