AC   MF_00956;
DC   Protein; auto
TR   HAMAP; MF_00956; -; 1; level=0
XX
Names: GDP_fucose_synth
XX
ID   FCL
DE   RecName: Full=GDP-L-fucose synthase;
DE            EC=1.1.1.271;
DE   AltName: Full=GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase;
GN   Name=fcl;
XX
CC   -!- FUNCTION: Catalyzes the two-step NADP-dependent conversion of GDP-4-
CC       dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a
CC       reductase reaction.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose +
CC         H(+) + NADPH; Xref=Rhea:RHEA:18885, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57273, ChEBI:CHEBI:57783, ChEBI:CHEBI:57964,
CC         ChEBI:CHEBI:58349; EC=1.1.1.271;
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via
CC       de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. Fucose synthase subfamily.
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DR   Pfam; PF01370; Epimerase; 1; trigger=no
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KW   Isomerase
KW   Multifunctional enzyme
KW   NADP
KW   Oxidoreductase
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GO   GO:0050577; F:GDP-L-fucose synthase activity
GO   GO:0070401; F:NADP+ binding
GO   GO:0042351; P:'de novo' GDP-L-fucose biosynthetic process
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FT   From: FCL_ECOLI (P32055)
FT   BINDING         10..16
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: G-x-x-G-x-x-G
FT   BINDING         105..108
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: [MILV]-[GA]-[ST]-[ST]
FT   BINDING         163..166
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: P-x-N-[IVL]
FT   ACT_SITE        136
FT                   /note="Proton donor/acceptor"
FT   Condition: [YF]
FT   BINDING         140
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: K
FT   BINDING         179
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: H
FT   BINDING         187
FT                   /ligand="substrate"
FT   Optional; Condition: [RK]
FT   BINDING         202
FT                   /ligand="substrate"
FT   Optional; Condition: W
FT   BINDING         209
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         278
FT                   /ligand="substrate"
FT   Optional; Condition: [DE]
FT   SITE            107
FT                   /note="Important for catalytic activity"
FT   Optional; Condition: [ST]
FT   SITE            109
FT                   /note="Important for catalytic activity"
FT   Optional; Condition: C
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Size: 280-440;
Related: None;
Template: P32055;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in SINFN
Comments: None
XX
# Revision 1.9 2022/11/19
//