AC   MF_00960;
DC   Protein; auto
TR   HAMAP; MF_00960; -; 1; level=0
XX
Names: ADH_synthase
XX
ID   ADHS
DE   RecName: Full=2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase;
DE            Short=ADH synthase;
DE            Short=ADHS;
DE            Short=ADTH synthase;
DE            EC=2.2.1.10;
GN   Name=aroA';
XX
CC   -!- FUNCTION: Catalyzes a transaldol reaction between 6-deoxy-5-
CC       ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with
CC       an elimination of hydroxypyruvaldehyde phosphate to yield 2-amino-3,7-
CC       dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an
CC       alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ),
CC       which is involved in the canonical pathway for the biosynthesis of
CC       aromatic amino acids.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate + L-aspartate 4-
CC         semialdehyde = 2,3-dioxopropyl phosphate + 2-amino-2,3,7-trideoxy-D-
CC         lyxo-hept-6-ulosonate; Xref=Rhea:RHEA:25952, ChEBI:CHEBI:58859,
CC         ChEBI:CHEBI:58860, ChEBI:CHEBI:58861, ChEBI:CHEBI:537519;
CC         EC=2.2.1.10;
CC   -!- SUBUNIT: Homodecamer.
CC   -!- SIMILARITY: Belongs to the DeoC/FbaB aldolase family. ADHS subfamily.
XX
DR   Pfam; PF01791; DeoC; 1; trigger=no
DR   NCBIfam; TIGR01949; AroFGH_arch; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   Aromatic amino acid biosynthesis
KW   Schiff base
KW   Transferase
XX
GO   GO:0016744; F:transketolase or transaldolase activity
GO   GO:0009073; P:aromatic amino acid family biosynthetic process
XX
FT   From: ADHS_METJA (Q57843)
FT   BINDING         33..37
FT                   /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58861"
FT   Optional; Condition: D-H-G-[VIM]-[ST]
FT   BINDING         153..155
FT                   /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58861"
FT   Optional; Condition: Y-x-R
FT   BINDING         209..210
FT                   /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58861"
FT   Optional; Condition: G-G
FT   BINDING         237..238
FT                   /ligand="1-deoxy-D-threo-hexo-2,5-diulose 6-phosphate"
FT                   /ligand_id="ChEBI:CHEBI:58861"
FT   Optional; Condition: G-R
FT   ACT_SITE        33
FT                   /note="Proton acceptor"
FT   Condition: D
FT   ACT_SITE        153
FT                   /note="Proton donor"
FT   Condition: Y
FT   ACT_SITE        184
FT                   /note="Schiff-base intermediate with substrate"
FT   Condition: K
XX
Size: 243-294;
Related: None;
Template: Q57843; Q6LZE3;
Scope:
 Bacteria; Aquificales
 Bacteria; Deltaproteobacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in ARCFU
Plasmid: None
Comments: None
XX
# Revision 1.9 2023/06/01
//