AC   MF_00963;
DC   Protein; auto
TR   HAMAP; MF_00963; -; 1; level=0
XX
Names: Sigma70_RpoD_SigA
XX
case <OC:Pseudomonadota> or <OC:Spirochaetales>
ID   RPOD
DE   RecName: Full=RNA polymerase sigma factor RpoD;
DE   AltName: Full=Sigma-70;
GN   Name=rpoD;
else
ID   SIGA
DE   RecName: Full=RNA polymerase sigma factor SigA;
GN   Name=sigA;
end case
XX
CC   -!- FUNCTION: Sigma factors are initiation factors that promote the
CC       attachment of RNA polymerase to specific initiation sites and are then
CC       released. This sigma factor is the primary sigma factor during
CC       exponential growth.
CC   -!- SUBUNIT: Interacts transiently with the RNA polymerase catalytic core.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the sigma-70 factor family. RpoD/SigA subfamily.
XX
DR   PROSITE; PS00715; SIGMA70_1; 1; trigger=no
DR   PROSITE; PS00716; SIGMA70_2; 1; trigger=no
DR   Pfam; PF04546; Sigma70_ner; 0-1; trigger=no
DR   Pfam; PF03979; Sigma70_r1_1; 0-1; trigger=no
DR   Pfam; PF00140; Sigma70_r1_2; 0-1; trigger=no
DR   Pfam; PF04542; Sigma70_r2; 1; trigger=no
DR   Pfam; PF04539; Sigma70_r3; 1; trigger=no
DR   Pfam; PF04545; Sigma70_r4; 1; trigger=no
DR   PRINTS; PR00046; SIGMA70FCT; 1; trigger=no
DR   NCBIfam; TIGR02393; RpoD_Cterm; 1; trigger=no
DR   NCBIfam; TIGR02937; sigma70-ECF; 1; trigger=no
DR   NCBIfam; TIGR02997; Sig70-cyanoRpoD; 0-1; trigger=no
XX
KW   Cytoplasm
KW   DNA-binding
KW   Sigma factor
KW   Transcription
KW   Transcription regulation
XX
GO   GO:0003677; F:DNA binding
GO   GO:0016987; F:sigma factor activity
GO   GO:0010468; P:regulation of gene expression
GO   GO:0006352; P:DNA-templated transcription initiation
GO   GO:0005737; C:cytoplasm
XX
FT   From: RPOD_ECOLI (P00579)
FT   DNA_BIND        573..592
FT                   /note="H-T-H motif"
FT   REGION          379..449
FT                   /note="Sigma-70 factor domain-2"
FT   REGION          458..534
FT                   /note="Sigma-70 factor domain-3"
FT   REGION          547..600
FT                   /note="Sigma-70 factor domain-4"
FT   MOTIF           403..406
FT                   /note="Interaction with polymerase core subunit RpoC"
FT   Condition: D-[LI]-[IVLF]-[QE]
XX
Size: 310-900;
Related: None;
Template: P00579; P0A0J0; P77994; Q72L95; Q9EZJ8;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: in PARP8, PARPJ, BURL3, BURSC, BURSG, PARXL, CALAS, CHLAA, CHLAD,
 CHLP6, CHLSY, LACP7, CLOSW, COREF, CORGL, CUPNH, CUPNN, CUPPJ, CUPTR, DEIDV,
 DEIPD, ECOLX, FRAAA, FRADG, FRACC, FRASN, FRASU, GEOS4, GLUDA, HALPG, HELPY,
 HERA2, LACD2, LACDN, MORCR, NITHN, NITOC, NITWC, NOCDD, OENOB, PIRSD, PLABD,
 CUPMC, RALSL, RIEPU, ROSCS, ROSS1, RUBXD, SANKS, SHIFL, SOLUE, SPHTD, STREN,
 STRRD, THEBD, THECD, THEFY, THEMA, TREPZ, VIBSE, YERPE
Plasmid: in BURSC, CUPNN, CUPPJ, CUPMC, TISMK
Comments: RpoD/SigA is the major sigma factor of most bacteria. Sequences,
 domains and nomenclature are highly variable. It is called RpoD in E.coli,
 and SigA in Bacillota and Actinomycetota.
XX
# Revision 1.21 2023/06/01
//