AC   MF_00966;
DC   Protein; auto
TR   HAMAP; MF_00966; -; 1; level=0
XX
Names: G6PD
XX
ID   G6PD
DE   RecName: Full=Glucose-6-phosphate 1-dehydrogenase;
DE            Short=G6PD;
DE            EC=1.1.1.49;
GN   Name=zwf;
XX
CC   -!- FUNCTION: Catalyzes the oxidation of glucose 6-phosphate to 6-
CC       phosphogluconolactone.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-
CC         lactone + H(+) + NADPH; Xref=Rhea:RHEA:15841, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57783, ChEBI:CHEBI:57955, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:61548; EC=1.1.1.49;
CC   -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway; D-
CC       ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step
CC       1/3.
CC   -!- SIMILARITY: Belongs to the glucose-6-phosphate dehydrogenase family.
XX
DR   PROSITE; PS00069; G6P_DEHYDROGENASE; 1; trigger=no
DR   Pfam; PF02781; G6PD_C; 1; trigger=no
DR   Pfam; PF00479; G6PD_N; 1; trigger=no
DR   PRINTS; PR00079; G6PDHDRGNASE; 1; trigger=no
DR   NCBIfam; TIGR00871; zwf; 1; trigger=no
DR   PIRSF; PIRSF000110; G6PD; 1; trigger=no
XX
KW   Carbohydrate metabolism
KW   Glucose metabolism
KW   NADP
KW   Oxidoreductase
XX
GO   GO:0004345; F:glucose-6-phosphate dehydrogenase activity
GO   GO:0050661; F:NADP binding
GO   GO:0006098; P:pentose-phosphate shunt
XX
FT   From: G6PD_LEUME (P11411)
FT   BINDING         13..20
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: G-[GAS]-[TS]-G-[DEN]-L-[AST]-[KR]
FT   BINDING         86..87
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: [DE]-[VLIF]
FT   ACT_SITE        241
FT                   /note="Proton acceptor"
FT   Condition: H
FT   BINDING         47
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: [RAS]
FT   BINDING         149
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT   Optional; Condition: K
FT   BINDING         179
FT                   /ligand="substrate"
FT   Optional; Condition: H
FT   BINDING         183
FT                   /ligand="substrate"
FT   Optional; Condition: K
FT   BINDING         217
FT                   /ligand="substrate"
FT   Optional; Condition: E
FT   BINDING         236
FT                   /ligand="substrate"
FT   Optional; Condition: D
FT   BINDING         339
FT                   /ligand="substrate"
FT   Optional; Condition: K
FT   BINDING         344
FT                   /ligand="substrate"
FT   Optional; Condition: K
XX
Size: 425-612;
Related: None;
Template: P11411; P0AC53; O68282; Q5FUK8;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Two members of the family (G6PD_LEUME and G6PD_PSEAE) can use either NADP(+) or NAD(+) and
 have a different EC number (EC 1.1.1.363). These are probably exceptions.
XX
# Revision 1.9 2023/06/01
//