AC   MF_00969;
DC   Protein; auto
TR   HAMAP; MF_00969; -; 1; level=0
XX
Names: TRCF
XX
ID   MFD
DE   RecName: Full=Transcription-repair-coupling factor;
DE            Short=TRCF;
DE            EC=3.6.4.-;
GN   Name=mfd;
XX
CC   -!- FUNCTION: Couples transcription and DNA repair by recognizing RNA
CC       polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent
CC       release of RNAP and its truncated transcript from the DNA, and
CC       recruitment of nucleotide excision repair machinery to the damaged
CC       site.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the UvrB family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the helicase family.
CC       RecG subfamily.
XX
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1; trigger=yes
DR   PROSITE; PS51194; HELICASE_CTER; 1; trigger=yes
DR   Pfam; PF02559; CarD_CdnL_TRCF; 1; trigger=no
DR   Pfam; PF00270; DEAD; 1; trigger=no
DR   Pfam; PF00271; Helicase_C; 1; trigger=no
DR   Pfam; PF03461; TRCF; 1; trigger=no
DR   NCBIfam; TIGR00580; mfd; 1; trigger=no
XX
KW   ATP-binding
KW   Cytoplasm
KW   DNA damage
KW   DNA repair
KW   DNA-binding
KW   Hydrolase
KW   Nucleotide-binding
XX
GO   GO:0005524; F:ATP binding
GO   GO:0003677; F:DNA binding
GO   GO:0006355; P:regulation of DNA-templated transcription
GO   GO:0000716; P:transcription-coupled nucleotide-excision repair, DNA damage recognition
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 700-1450;
Related: None;
Template: P30958;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.6 2023/06/01
//