AC   MF_00972;
DC   Protein; auto
TR   HAMAP; MF_00972; -; 1; level=0
XX
Names: tRNA_aden_deaminase
XX
ID   TADA
DE   RecName: Full=tRNA-specific adenosine deaminase;
DE            EC=3.5.4.33;
GN   Name=tadA;
XX
CC   -!- FUNCTION: Catalyzes the deamination of adenosine to inosine at the
CC       wobble position 34 of tRNA(Arg2).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA +
CC         NH4(+); Xref=Rhea:RHEA:43168, Rhea:RHEA-COMP:10373, Rhea:RHEA-
CC         COMP:10374, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:28938,
CC         ChEBI:CHEBI:74411, ChEBI:CHEBI:82852; EC=3.5.4.33;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase
CC       family.
XX
DR   PROSITE; PS00903; CYT_DCMP_DEAMINASES_1; 1; trigger=no
DR   PROSITE; PS51747; CYT_DCMP_DEAMINASES_2; 1; trigger=yes
DR   Pfam; PF00383; dCMP_cyt_deam_1; 1; trigger=yes
XX
KW   Hydrolase
KW   tRNA processing
case <FTGroup:1>
KW   Metal-binding
KW   Zinc
end case
XX
GO   GO:0052717; F:tRNA-specific adenosine-34 deaminase activity
GO   GO:0002100; P:tRNA wobble adenosine to inosine editing
case <FTGroup:1>
GO   GO:0008270; F:zinc ion binding
end case
XX
FT   From: TADA_ECOLI (P68398)
FT   ACT_SITE        59
FT                   /note="Proton donor"
FT   Condition: E
FT   BINDING         57
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: H
FT   BINDING         87
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: C
FT   BINDING         90
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT   Group: 1; Condition: C
XX
Size: 114-252;
Related: None;
Template: P68398; O67050; Q5XE14; A9CK16; Q99W51;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.8 2022/11/19
//