AC   MF_00978;
DC   Protein; auto
c?   <OC:Bacteria>
TR   HAMAP; MF_00978; -; 1; level=0
XX
Names: Bifunct_BirA
XX
ID   BIRA
case <OC:Gammaproteobacteria>
DE   RecName: Full=Bifunctional ligase/repressor BirA;
DE   AltName: Full=Biotin--[acetyl-CoA-carboxylase] ligase;
DE            EC=6.3.4.15;
DE   AltName: Full=Biotin--protein ligase;
DE   AltName: Full=Biotin-[acetyl-CoA carboxylase] synthetase;
DE   AltName: Full=Biotin operon repressor;
else
DE   RecName: Full=Bifunctional ligase/repressor BirA;
DE   AltName: Full=Biotin--[acetyl-CoA-carboxylase] ligase;
DE            EC=6.3.4.15;
DE   AltName: Full=Biotin--protein ligase;
DE   AltName: Full=Biotin-[acetyl-CoA carboxylase] synthetase;
end case
GN   Name=birA;
XX
case <OC:Gammaproteobacteria>
CC   -!- FUNCTION: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a
CC       biotin-operon repressor. In the presence of ATP, BirA activates biotin
CC       to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA)
CC       complex. HoloBirA can either transfer the biotinyl moiety to the biotin
CC       carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or
CC       bind to the biotin operator site and inhibit transcription of the
CC       operon.
else
CC   -!- FUNCTION: Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a
CC       repressor.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) +
CC         N(6)-biotinyl-L-lysyl-[protein]; Xref=Rhea:RHEA:11756, Rhea:RHEA-
CC         COMP:9752, Rhea:RHEA-COMP:10505, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29969, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:57586, ChEBI:CHEBI:83144, ChEBI:CHEBI:456215;
CC         EC=6.3.4.15;
CC   -!- SIMILARITY: Belongs to the biotin--protein ligase family.
XX
DR   PROSITE; PS51733; BPL_LPL_CATALYTIC; 1; trigger=yes
DR   Pfam; PF02237; BPL_C; 1; trigger=no
DR   Pfam; PF03099; BPL_LplA_LipB; 1; trigger=no
DR   Pfam; PF08279; HTH_11; 1; trigger=no
DR   NCBIfam; TIGR00121; birA_ligase; 1; trigger=no
DR   NCBIfam; TIGR00122; birA_repr_reg; 1; trigger=no
XX
KW   ATP-binding
KW   Biotin
KW   DNA-binding
KW   Ligase
KW   Nucleotide-binding
KW   Repressor
KW   Transcription
KW   Transcription regulation
XX
GO   GO:0005524; F:ATP binding
GO   GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity
GO   GO:0003677; F:DNA binding
GO   GO:0006355; P:regulation of DNA-templated transcription
XX
FT   From: BIRA_ECOLI (P06709)
FT   DNA_BIND        22..41
FT                   /note="H-T-H motif"
FT   BINDING         89..91
FT                   /ligand="biotin"
FT                   /ligand_id="ChEBI:CHEBI:57586"
FT   Optional; Condition: [ST]-[ST]-N
FT   BINDING         116..118
FT                   /ligand="biotin"
FT                   /ligand_id="ChEBI:CHEBI:57586"
FT   Optional; Condition: R-G-R
FT   BINDING         112
FT                   /ligand="biotin"
FT                   /ligand_id="ChEBI:CHEBI:57586"
FT   Optional; Condition: Q
FT   BINDING         183
FT                   /ligand="biotin"
FT                   /ligand_id="ChEBI:CHEBI:57586"
FT   Optional; Condition: K
XX
Size: 280-400;
Related: None;
Template: P06709;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.13 2023/06/01
//