AC   MF_00979;
DC   Protein; auto
TR   HAMAP; MF_00979; -; 1; level=0
XX
Names: RcsC
XX
ID   RCSC
DE   RecName: Full=Sensor histidine kinase RcsC;
DE            EC=2.7.13.3;
GN   Name=rcsC;
XX
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. RcsC functions as a membrane-
CC       associated protein kinase that phosphorylates RcsD in response to
CC       environmental signals. The phosphoryl group is then transferred to the
CC       response regulator RcsB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC         histidine.; EC=2.7.13.3;
CC   -!- SUBUNIT: Interacts with RcsD.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
CC   -!- PTM: Autophosphorylated. Activation probably requires a transfer of a
CC       phosphate group from a His in the transmitter domain to an Asp in the
CC       receiver domain.
CC   -!- SIMILARITY: Belongs to the RcsC family.
XX
DR   PROSITE; PS51426; ABL; 1; trigger=yes
DR   PROSITE; PS50109; HIS_KIN; 1; trigger=yes
DR   PROSITE; PS50112; PAS; 1; trigger=yes
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1; trigger=yes
DR   Pfam; PF02518; HATPase_c; 1; trigger=no
DR   Pfam; PF00512; HisKA; 1; trigger=no
DR   Pfam; PF09456; RcsC; 1; trigger=no
DR   Pfam; PF00072; Response_reg; 1; trigger=no
DR   PRINTS; PR00344; BCTRLSENSOR; 1; trigger=no
DR   General; Transmembrane; -; 2; trigger=yes
XX
KW   ATP-binding
KW   Cell inner membrane
KW   Cell membrane
KW   Kinase
KW   Membrane
KW   Nucleotide-binding
KW   Phosphoprotein
KW   Transferase
KW   Transmembrane
KW   Transmembrane helix
KW   Two-component regulatory system
XX
GO   GO:0005524; F:ATP binding
GO   GO:0000155; F:phosphorelay sensor kinase activity
GO   GO:0046777; P:protein autophosphorylation
GO   GO:0000160; P:phosphorelay signal transduction system
GO   GO:0005886; C:plasma membrane
XX
FT   From: RCSC_ECOLI (P0DMC5)
FT   MOD_RES         479
FT                   /note="Phosphohistidine; by autocatalysis"
FT   Condition: H
FT   MOD_RES         875
FT                   /note="4-aspartylphosphate"
FT   Condition: D
XX
Size: 900-1000;
Related: None;
Template: P0DMC5;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.7 2022/09/29
//