AC   MF_00990;
DC   Protein; auto
TR   HAMAP; MF_00990; -; 1; level=0
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Names: L_hydroxyglutarate_dehydrogenase
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ID   LHGD
DE   RecName: Full=L-2-hydroxyglutarate dehydrogenase;
DE            Short=L2HG dehydrogenase;
DE            EC=1.1.5.13;
DE   AltName: Full=L2HG:quinone oxidoreductase;
GN   Name=lhgD;
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CC   -!- FUNCTION: Catalyzes the dehydrogenation of L-2-hydroxyglutarate (L2HG)
CC       to alpha-ketoglutarate and couples to the respiratory chain by feeding
CC       electrons from the reaction into the membrane quinone pool. Functions
CC       in a L-lysine degradation pathway that proceeds via cadaverine,
CC       glutarate and L-2-hydroxyglutarate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(S)-2-hydroxyglutarate + a quinone = 2-oxoglutarate + a
CC         quinol; Xref=Rhea:RHEA:58664, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:24646, ChEBI:CHEBI:132124; EC=1.1.5.13;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:58665;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC   -!- PATHWAY: Amino-acid degradation.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane.
CC   -!- SIMILARITY: Belongs to the L2HGDH family.
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DR   Pfam; PF01266; DAO; 1; trigger=no
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KW   Cell inner membrane
KW   Cell membrane
KW   Membrane
KW   Electron transport
KW   FAD
KW   Flavoprotein
KW   Oxidoreductase
KW   Transport
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GO   GO:0016901; F:oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor
GO   GO:0047545; F:2-hydroxyglutarate dehydrogenase activity
GO   GO:0050660; F:flavin adenine dinucleotide binding
GO   GO:0019477; P:L-lysine catabolic process
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Size: 410-450;
Related: None;
Template: P37339;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.10 2020/02/28
//