AC   MF_00992;
DC   Protein; auto
TR   HAMAP; MF_00992; -; 1; level=0
XX
Names: MqnC
XX
ID   MQNC
DE   RecName: Full=Cyclic dehypoxanthine futalosine synthase;
DE            Short=Cyclic DHFL synthase;
DE            EC=1.21.98.1;
DE   AltName: Full=Dehypoxanthine futalosine cyclase;
DE            Short=DHFL cyclase;
DE   AltName: Full=Menaquinone biosynthetic enzyme MqnC;
GN   Name=mqnC;
XX
CC   -!- FUNCTION: Radical SAM enzyme that catalyzes the cyclization of
CC       dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine
CC       (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-
CC         deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-
CC         methionine; Xref=Rhea:RHEA:33083, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17319, ChEBI:CHEBI:57844, ChEBI:CHEBI:58864,
CC         ChEBI:CHEBI:59789, ChEBI:CHEBI:64270; EC=1.21.98.1;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3
CC       cysteines and an exchangeable S-adenosyl-L-methionine.;
end case
CC   -!- PATHWAY: Quinol/quinone metabolism; menaquinone biosynthesis.
CC   -!- SIMILARITY: Belongs to the radical SAM superfamily. MqnC family.
XX
DR   Pfam; PF04055; Radical_SAM; 1; trigger=no
DR   NCBIfam; TIGR03699; mena_SCO4550; 1; trigger=no
DR   NCBIfam; TIGR00423; TIGR00423; 1; trigger=no
DR   PIRSF; PIRSF004762; CHP00423; 1; trigger=no
DR   PROSITE; PS51918; RADICAL_SAM; 1; trigger=yes
XX
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
KW   S-adenosyl-L-methionine
end case
KW   Menaquinone biosynthesis
KW   Oxidoreductase
XX
case <FTGroup:1>
GO   GO:0005506; F:iron ion binding
end case
GO   GO:0046992; F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond
GO   GO:0009234; P:menaquinone biosynthetic process
XX
FT   From: MQNC_HALH5 (Q9K864)
FT   BINDING         64
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
FT   BINDING         68
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
FT   BINDING         71
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT                   /ligand_note="4Fe-4S-S-AdoMet"
FT   Group: 1; Condition: C
XX
Size: 325-500;
Related: None;
Template: Q9K864; Q9XAP2;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.15 2023/06/01
//