AC   MF_00994;
DC   Protein; auto
TR   HAMAP; MF_00994; -; 1; level=0
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Names: LPS_assembly_LapB
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ID   LAPB
DE   RecName: Full=Lipopolysaccharide assembly protein B;
GN   Name=lapB;
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CC   -!- FUNCTION: Modulates cellular lipopolysaccharide (LPS) levels by
CC       regulating LpxC, which is involved in lipid A biosynthesis. Regulates
CC       the proteolytic activity of FtsH towards LpxC by acting as an adapter
CC       protein which interacts with FtsH via its transmembrane helices while
CC       its cytoplasmic domain recruits LpxC for degradation by FtsH. May also
CC       coordinate assembly of proteins involved in LPS synthesis at the plasma
CC       membrane.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Single-pass membrane
CC       protein; Cytoplasmic side.
CC   -!- SIMILARITY: Belongs to the LapB family.
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DR   PROSITE; PS50005; TPR; 1; trigger=no
DR   PROSITE; PS50293; TPR_REGION; 1; trigger=no
DR   Pfam; PF07719; TPR_2; 1; trigger=no
DR   Pfam; PF13176; TPR_7; 1; trigger=no
DR   Pfam; PF00515; TPR_1; 1; trigger=no
DR   REP; Repeat_TPR; TPR; 2-7; trigger=yes
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KW   Cell inner membrane
KW   Cell membrane
KW   Membrane
KW   Repeat
KW   TPR repeat
KW   Transmembrane
KW   Transmembrane helix
case <FTGroup:1>
KW   Iron
KW   Metal-binding
end case
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case <FTGroup:1>
GO   GO:0005506; F:iron ion binding
end case
GO   GO:0046890; P:regulation of lipid biosynthetic process
GO   GO:0009898; C:cytoplasmic side of plasma membrane
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FT   From: LAPB_ECOLI (P0AB58)
FT   TRANSMEM        1..20
FT                   /note="Helical"
FT   TOPO_DOM        21..Cter
FT                   /note="Cytoplasmic"
FT   BINDING         357
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Group: 1; Condition: C
FT   BINDING         360
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Group: 1; Condition: C
FT   BINDING         371
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Group: 1; Condition: C
FT   BINDING         374
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Group: 1; Condition: C
XX
Size: 350-430;
Related: None;
Template: P0AB58;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Version: 10
# Last updated date: 2025-08-29
# Created date: 2014-02-14
//