AC   MF_01001;
DC   Protein; auto
TR   HAMAP; MF_01001; -; 1; level=0
XX
Names: WecG_RffM
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ID   WECG
DE   RecName: Full=UDP-N-acetyl-D-mannosaminuronic acid transferase;
DE            Short=UDP-ManNAcA transferase;
DE            EC=2.4.1.180;
GN   Name=wecG; Synonyms=rffM;
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CC   -!- FUNCTION: Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA (Lipid II),
CC       the second lipid-linked intermediate involved in enterobacterial common
CC       antigen (ECA) synthesis.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl
CC         diphosphate + UDP-N-acetyl-alpha-D-mannosaminouronate = beta-D-
CC         ManNAcA-(1->4)-alpha-D-GlcNAc-di-trans,octa-cis-undecaprenyl
CC         diphosphate + H(+) + UDP; Xref=Rhea:RHEA:28366, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58223, ChEBI:CHEBI:61495, ChEBI:CHEBI:62959,
CC         ChEBI:CHEBI:70731; EC=2.4.1.180;
CC   -!- PATHWAY: Bacterial outer membrane biogenesis; enterobacterial common
CC       antigen biosynthesis.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 26 family.
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DR   Pfam; PF03808; Glyco_tran_WecB; 1; trigger=no
DR   NCBIfam; TIGR00696; WecB_tagA_cpsF; 1; trigger=no
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KW   Transferase
KW   Glycosyltransferase
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GO   GO:0047241; F:lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GO   GO:0009246; P:enterobacterial common antigen biosynthetic process
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FT   None
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Size: 235-260;
Related: None;
Template: P27836;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.25 2023/06/01
//