AC   MF_01010;
DC   Protein; auto
TR   HAMAP; MF_01010; -; 1; level=0
XX
Names: 23SrRNA_methyltr_RlmD
XX
ID   RLMD
DE   RecName: Full=23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD;
DE            EC=2.1.1.190;
DE   AltName: Full=23S rRNA(m5U1939)-methyltransferase;
GN   Name=rlmD;
XX
CC   -!- FUNCTION: Catalyzes the formation of 5-methyl-uridine at position 1939
CC       (m5U1939) in 23S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(1939) in 23S rRNA = 5-
CC         methyluridine(1939) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42908, Rhea:RHEA-COMP:10278, Rhea:RHEA-COMP:10279,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74447; EC=2.1.1.190;
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA M5U methyltransferase family. RlmD subfamily.
XX
DR   Pfam; PF01938; TRAM; 1; trigger=no
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1; trigger=no
DR   NCBIfam; TIGR00479; RumA; 1; trigger=no
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1; trigger=no
DR   PROSITE; PS50926; TRAM; 0-1; trigger=yes
DR   PROSITE; PS01230; TRMA_1; 1; trigger=no
DR   PROSITE; PS01231; TRMA_2; 1; trigger=no
XX
KW   Methyltransferase
KW   rRNA processing
KW   S-adenosyl-L-methionine
KW   Transferase
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
end case
XX
GO   GO:0070041; F:rRNA (uridine-C5-)-methyltransferase activity
case <FTGroup:1>
GO   GO:0005506; F:iron ion binding
end case
GO   GO:0031167; P:rRNA methylation
XX
FT   From: RLMD_ECOLI (P55135)
FT   ACT_SITE        389
FT                   /note="Nucleophile"
FT   Condition: C
FT   BINDING         81
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         87
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         90
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         162
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         265
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Q
FT   BINDING         294
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: F
FT   BINDING         299
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: N
FT   BINDING         315
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: E
FT   BINDING         342
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: [ND]
FT   BINDING         363
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: D
XX
Size: 431-514;
Related: MF_01011;
Template: P55135;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.33 2023/06/01
//