AC   MF_01012;
DC   Protein; auto
TR   HAMAP; MF_01012; -; 1; level=0
XX
Names: 23SrRNA_methyltr_RlmC
XX
ID   RLMC
DE   RecName: Full=23S rRNA (uracil(747)-C(5))-methyltransferase RlmC;
DE            EC=2.1.1.189;
DE   AltName: Full=23S rRNA(m5U747)-methyltransferase;
GN   Name=rlmC;
XX
CC   -!- FUNCTION: Catalyzes the formation of 5-methyl-uridine at position 747
CC       (m5U747) in 23S rRNA.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=S-adenosyl-L-methionine + uridine(747) in 23S rRNA = 5-
CC         methyluridine(747) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42628, Rhea:RHEA-COMP:10154, Rhea:RHEA-COMP:10155,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:65315, ChEBI:CHEBI:74447; EC=2.1.1.189;
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. RNA M5U methyltransferase family. RlmC subfamily.
XX
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1; trigger=no
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1; trigger=no
DR   PROSITE; PS01230; TRMA_1; 1; trigger=no
DR   PROSITE; PS01231; TRMA_2; 1; trigger=no
DR   NCBIfam; TIGR02085; Meth_trns_rumB; 1; trigger=no
XX
KW   Methyltransferase
KW   rRNA processing
KW   S-adenosyl-L-methionine
KW   Transferase
case <FTGroup:1>
KW   4Fe-4S
KW   Iron
KW   Iron-sulfur
KW   Metal-binding
end case
XX
GO   GO:0070041; F:rRNA (uridine-C5-)-methyltransferase activity
case <FTGroup:1>
GO   GO:0005506; F:iron ion binding
end case
GO   GO:0031167; P:rRNA methylation
XX
FT   From: RLMC_ECOLI (P75817)
FT   ACT_SITE        334
FT                   /note="Nucleophile"
FT   Condition: C
FT   BINDING         3
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         11
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         14
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         87
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         212
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: Q
FT   BINDING         241
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: F
FT   BINDING         262
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: E
FT   BINDING         307
FT                   /ligand="S-adenosyl-L-methionine"
FT                   /ligand_id="ChEBI:CHEBI:59789"
FT   Condition: N
XX
Size: 375-392;
Related: None;
Template: P75817; P55135;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.26 2023/06/01
//