AC   MF_01013;
DC   Protein; auto
TR   HAMAP; MF_01013; -; 1; level=0
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Names: HisF
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ID   HIS6
DE   RecName: Full=Imidazole glycerol phosphate synthase subunit HisF;
DE            EC=4.3.2.10;
DE   AltName: Full=IGP synthase cyclase subunit;
DE   AltName: Full=IGP synthase subunit HisF;
DE   AltName: Full=ImGP synthase subunit HisF;
DE            Short=IGPS subunit HisF;
GN   Name=hisF;
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CC   -!- FUNCTION: IGPS catalyzes the conversion of PRFAR and glutamine to IGP,
CC       AICAR and glutamate. The HisF subunit catalyzes the cyclization
CC       activity that produces IGP and AICAR from PRFAR using the ammonia
CC       provided by the HisH subunit.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-
CC         phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-
CC         amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-
CC         erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate;
CC         Xref=Rhea:RHEA:24793, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985,
CC         ChEBI:CHEBI:58278, ChEBI:CHEBI:58359, ChEBI:CHEBI:58475,
CC         ChEBI:CHEBI:58525; EC=4.3.2.10;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.
CC   -!- SUBUNIT: Heterodimer of HisH and HisF.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the HisA/HisF family.
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DR   Pfam; PF00977; His_biosynth; 1; trigger=no
DR   NCBIfam; TIGR00735; HisF; 1; trigger=no
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KW   Cytoplasm
KW   Amino-acid biosynthesis
KW   Histidine biosynthesis
KW   Lyase
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GO   GO:0000107; F:imidazoleglycerol-phosphate synthase activity
GO   GO:0000105; P:histidine biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: HIS6_THEMA (Q9X0C6)
FT   ACT_SITE        11
FT   Condition: D
FT   ACT_SITE        130
FT   Condition: [DE]
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Size: 212-281;
Related: MF_01014;
Template: P60664; Q9X0C6; Q7SIB9; Q8ZY16;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in CAMJE, LEPIN, PROMM, PSEAE, PARMW, VIBVY
Plasmid: None
Comments: First active site problem in LEPBO and in the second copy of CAMJE, LEPIN,
 PROMM, PSEAE, PARMW and VIBVY; sequences not included in alignment
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# Revision 1.39 2023/06/01
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