AC   MF_01014;
DC   Protein; auto
TR   HAMAP; MF_01014; -; 1; level=0
XX
Names: HisA
XX
ID   HIS4
case not <OC:Mycobacteriaceae> and not <OC:Streptomycetaceae>
DE   RecName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=hisA;
end case
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
DE   RecName: Full=Phosphoribosyl isomerase A;
DE   AltName: Full=1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase;
DE            EC=5.3.1.16;
DE   AltName: Full=N-(5'-phosphoribosyl)anthranilate isomerase;
DE            Short=PRAI;
DE            EC=5.3.1.24;
DE   AltName: Full=Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase;
GN   Name=priA; Synonyms=hisA;
end case
XX
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
CC   -!- FUNCTION: Involved in both the histidine and tryptophan biosynthetic
CC       pathways.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-
CC         ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-
CC         phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-
CC         ribosyl)imidazole-4-carboxamide; Xref=Rhea:RHEA:15469,
CC         ChEBI:CHEBI:58435, ChEBI:CHEBI:58525; EC=5.3.1.16;
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-
CC         carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate;
CC         Xref=Rhea:RHEA:21540, ChEBI:CHEBI:18277, ChEBI:CHEBI:58613;
CC         EC=5.3.1.24;
end case
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
CC   -!- PATHWAY: Amino-acid biosynthesis; L-tryptophan biosynthesis; L-
CC       tryptophan from chorismate: step 3/5.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the HisA/HisF family.
XX
DR   Pfam; PF00977; His_biosynth; 1; trigger=no
DR   NCBIfam; TIGR00007; TIGR00007; 0-1; trigger=no
DR   NCBIfam; TIGR01919; hisA-trpF; 0-1; trigger=no
XX
KW   Cytoplasm
KW   Isomerase
KW   Amino-acid biosynthesis
KW   Histidine biosynthesis
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
KW   Aromatic amino acid biosynthesis
KW   Tryptophan biosynthesis
end case
XX
GO   GO:0003949; F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
GO   GO:0004640; F:phosphoribosylanthranilate isomerase activity
end case
GO   GO:0000105; P:histidine biosynthetic process
case <OC:Mycobacteriaceae> or <OC:Streptomycetaceae>
GO   GO:0000162; P:tryptophan biosynthetic process
end case
GO   GO:0005737; C:cytoplasm
XX
FT   From: HIS4_THEMA (Q9X0C7)
FT   ACT_SITE        8
FT                   /note="Proton acceptor"
FT   Condition: [DE]
FT   ACT_SITE        127
FT                   /note="Proton donor"
FT   Condition: [DE]
XX
Size: 229-269;
Related: MF_01013;
Template: Q9X0C7; P16250; P9WMM5;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in PHOLL, RUEPO
Plasmid: None
Comments: None
XX
# Revision 1.42 2023/06/01
//