AC   MF_01018;
DC   Protein; auto
TR   HAMAP; MF_01018; -; 1; level=0
XX
Names: HisG_Short
XX
ID   HIS1
DE   RecName: Full=ATP phosphoribosyltransferase;
DE            Short=ATP-PRT;
DE            Short=ATP-PRTase;
DE            EC=2.4.2.17;
GN   Name=hisG;
XX
CC   -!- FUNCTION: Catalyzes the condensation of ATP and 5-phosphoribose 1-
CC       diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial
CC       role in the pathway because the rate of histidine biosynthesis seems to
CC       be controlled primarily by regulation of HisG enzymatic activity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-
CC         alpha-D-ribose 1-diphosphate + ATP; Xref=Rhea:RHEA:18473,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:58017,
CC         ChEBI:CHEBI:73183; EC=2.4.2.17;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.
case <OC:Bacteria>
CC   -!- SUBUNIT: Heteromultimer composed of HisG and HisZ subunits.
end case
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
case <OC:Bacteria>
CC   -!- DOMAIN: Lacks the C-terminal regulatory region which is replaced by
CC       HisZ.
end case
CC   -!- SIMILARITY: Belongs to the ATP phosphoribosyltransferase family. Short
CC       subfamily.
XX
DR   Pfam; PF01634; HisG; 1; trigger=no
DR   NCBIfam; TIGR00070; HisG; 1; trigger=no
DR   PROSITE; PS01316; ATP_P_PHORIBOSYLTR; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   ATP-binding
KW   Cytoplasm
KW   Glycosyltransferase
KW   Histidine biosynthesis
KW   Nucleotide-binding
KW   Transferase
XX
GO   GO:0003879; F:ATP phosphoribosyltransferase activity
GO   GO:0000105; P:histidine biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 203-241;
Related: MF_00079!;
Template: Q02129;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: See MF_00079 for the entry relevant to the "long" hisG
XX
# Revision 1.37 2023/06/01
//