AC   MF_01019;
DC   Protein; auto
TR   HAMAP; MF_01019; -; 1; level=0
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Names: HisIE
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ID   HIS2
DE   RecName: Full=Histidine biosynthesis bifunctional protein HisIE;
DE   Includes:
DE     RecName: Full=Phosphoribosyl-AMP cyclohydrolase;
DE              Short=PRA-CH;
DE              EC=3.5.4.19;
DE   Includes:
DE     RecName: Full=Phosphoribosyl-ATP pyrophosphatase;
DE              Short=PRA-PH;
DE              EC=3.6.1.31;
GN   Name=hisI; Synonyms=hisIE;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-
CC         ribosyl)-5'-AMP + diphosphate + H(+); Xref=Rhea:RHEA:22828,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:59457, ChEBI:CHEBI:73183; EC=3.6.1.31;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-
CC         D-ribosyl)-5-[(5-phospho-beta-D-
CC         ribosylamino)methylideneamino]imidazole-4-carboxamide;
CC         Xref=Rhea:RHEA:20049, ChEBI:CHEBI:15377, ChEBI:CHEBI:58435,
CC         ChEBI:CHEBI:59457; EC=3.5.4.19;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: In the N-terminal section; belongs to the PRA-CH family.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the PRA-PH family.
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DR   Pfam; PF01502; PRA-CH; 1; trigger=no
DR   Pfam; PF01503; PRA-PH; 1; trigger=no
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KW   Amino-acid biosynthesis
KW   ATP-binding
KW   Cytoplasm
KW   Histidine biosynthesis
KW   Hydrolase
KW   Multifunctional enzyme
KW   Nucleotide-binding
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GO   GO:0004635; F:phosphoribosyl-AMP cyclohydrolase activity
GO   GO:0004636; F:phosphoribosyl-ATP diphosphatase activity
GO   GO:0000105; P:histidine biosynthetic process
GO   GO:0005737; C:cytoplasm
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FT   From: HIS2_ECOLI (P06989)
FT   REGION          Nter..114
FT                   /note="Phosphoribosyl-AMP cyclohydrolase"
FT   REGION          115..Cter
FT                   /note="Phosphoribosyl-ATP pyrophosphohydrolase"
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Size: 184-300;
Related: MF_01020; MF_01021;
Template: O82768; P06989;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: See MF_01020 and MF_01021 for the entries relevant to hisI and hisE
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# Revision 1.32 2019/11/19
//