AC   MF_01020;
DC   Protein; auto
TR   HAMAP; MF_01020; -; 1; level=0
XX
Names: HisE
XX
ID   HIS2
DE   RecName: Full=Phosphoribosyl-ATP pyrophosphatase;
DE            Short=PRA-PH;
DE            EC=3.6.1.31;
GN   Name=hisE;
XX
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-
CC         ribosyl)-5'-AMP + diphosphate + H(+); Xref=Rhea:RHEA:22828,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:59457, ChEBI:CHEBI:73183; EC=3.6.1.31;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the PRA-PH family.
XX
DR   Pfam; PF01503; PRA-PH; 1; trigger=no
DR   NCBIfam; TIGR03188; histidine_hisI; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   ATP-binding
KW   Cytoplasm
KW   Histidine biosynthesis
KW   Hydrolase
KW   Nucleotide-binding
XX
GO   GO:0004636; F:phosphoribosyl-ATP diphosphatase activity
GO   GO:0000105; P:histidine biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   None
XX
Size: 87-160;
Related: MF_01019!;
Template: P06989;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in BRADU, RHOPA
Plasmid: None
Comments: See MF_01019 for the entry relevant to the fused hisI-hisE
XX
# Revision 1.36 2023/06/01
//