AC   MF_01021;
DC   Protein; auto
TR   HAMAP; MF_01021; -; 1; level=0
XX
Names: HisI
XX
ID   HIS3
DE   RecName: Full=Phosphoribosyl-AMP cyclohydrolase;
DE            Short=PRA-CH;
DE            EC=3.5.4.19;
GN   Name=hisI;
XX
CC   -!- FUNCTION: Catalyzes the hydrolysis of the adenine ring of
CC       phosphoribosyl-AMP.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-
CC         D-ribosyl)-5-[(5-phospho-beta-D-
CC         ribosylamino)methylideneamino]imidazole-4-carboxamide;
CC         Xref=Rhea:RHEA:20049, ChEBI:CHEBI:15377, ChEBI:CHEBI:58435,
CC         ChEBI:CHEBI:59457; EC=3.5.4.19;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC       Note=Binds 1 Mg(2+) ion per subunit.;
end case
case <FTGroup:2>
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC       Note=Binds 1 zinc ion per subunit.;
end case
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the PRA-CH family.
XX
DR   Pfam; PF01502; PRA-CH; 1; trigger=no
XX
KW   Amino-acid biosynthesis
KW   Cytoplasm
KW   Histidine biosynthesis
KW   Hydrolase
case <FTGroup:1>
KW   Magnesium
end case
case <FTGroup:2>
KW   Zinc
end case
case <FTGroup:1> or <FTGroup:2>
KW   Metal-binding
end case
XX
GO   GO:0004635; F:phosphoribosyl-AMP cyclohydrolase activity
case <FTGroup:1>
GO   GO:0000287; F:magnesium ion binding
end case
case <FTGroup:2>
GO   GO:0008270; F:zinc ion binding
end case
GO   GO:0000105; P:histidine biosynthetic process
GO   GO:0005737; C:cytoplasm
XX
FT   From: HIS3_METTH (O26347)
FT   BINDING         85
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: D
FT   BINDING         86
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Group: 2; Condition: C
FT   BINDING         87
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: D
FT   BINDING         89
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT   Group: 1; Condition: D
FT   BINDING         102
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Group: 2; Condition: C
FT   BINDING         109
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="ligand shared between dimeric partners"
FT   Group: 2; Condition: C
XX
Size: 101-180;
Related: MF_01019!;
Template: O26347; Q50837; P06989;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in PSEF5
Plasmid: in TRIV2
Comments: Possible wrong start in LEPIN and SACS2; not shown in alignment and not
 taken into account in size range.
 See MF_01019 for the entry relevant to the fused hisI-hisE.
XX
# Revision 1.38 2022/11/19
//