AC   MF_01023;
DC   Protein; auto
TR   HAMAP; MF_01023; -; 1; level=0
XX
Names: HisC_aminotrans_2
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ID   HIS8
DE   RecName: Full=Histidinol-phosphate aminotransferase;
DE            EC=2.6.1.9;
DE   AltName: Full=Imidazole acetol-phosphate transaminase;
GN   Name=hisC;
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CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-
CC         oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744,
CC         ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766,
CC         ChEBI:CHEBI:57980; EC=2.6.1.9;
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine
CC       from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.
case <OC:Bacteria>
CC   -!- SUBUNIT: Homodimer.
end case
CC   -!- SIMILARITY: Belongs to the class-II pyridoxal-phosphate-dependent
CC       aminotransferase family. Histidinol-phosphate aminotransferase
CC       subfamily.
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DR   Pfam; PF00155; Aminotran_1_2; 1; trigger=no
DR   NCBIfam; TIGR01141; HisC; 1; trigger=no
DR   PROSITE; PS00599; AA_TRANSFER_CLASS_2; 1; trigger=no
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KW   Amino-acid biosynthesis
KW   Histidine biosynthesis
KW   Transferase
KW   Aminotransferase
KW   Pyridoxal phosphate
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GO   GO:0004400; F:histidinol-phosphate transaminase activity
GO   GO:0000105; P:histidine biosynthetic process
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FT   From: HIS8_ECOLI (P06986)
FT   MOD_RES         214
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT   Condition: K
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Size: 335-401;
Related: MF_01513!;
Template: P06986; Q9X0D0;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: MF_01024 (hisD)
 Cter: None
Duplicate: in NOSS1, TRIV2, ARCFU, BACAN, BACC1, BACCR, BACCZ, BACHK, BORBR,
 BORPA, BORPE, BRADU, BURMA, BURP1, BURPS, BURL3, CARHZ, CAUVC, DECAR, GLUOX,
 HAEIN, HAEI8, IDILO, LEGPL, LEGPA, LEGPH, MANSM, METCA, NITEU, NITMU, NITOC,
 OCEIH, PASMU, PSEAE, PSEF5, PSEPF, PSYA2, CUPPJ, RALN1, RHILO, RHIME, HYDCU,
 THIDA
Plasmid: in RHIME, SINFN
Comments: Shorter N-terminal in SULTO and in the first copy of hisC in ARCFU; not shown
 in alignment and not taken into account in size range.
 Difficulty to distinguish between hisC and other class-II pyridoxal-phosphate-dependent
 aminotransferases.
 PHOLL is a fusion between hisC and hisD. As other Enterobacteriaceae do not
 have such a fusion, this could be a sequencing artefact.
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# Revision 1.46 2023/11/28
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