AC   MF_01028;
DC   Protein; auto
TR   HAMAP; MF_01028; -; 1; level=0
XX
Names: CimA
XX
ID   CIMA
DE   RecName: Full=Putative (R)-citramalate synthase CimA;
DE            EC=2.3.3.21;
GN   Name=cimA;
XX
CC   -!- FUNCTION: Catalyzes the condensation of pyruvate and acetyl-coenzyme A
CC       to form (R)-citramalate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+);
CC         Xref=Rhea:RHEA:19045, ChEBI:CHEBI:15361, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:30934, ChEBI:CHEBI:57287,
CC         ChEBI:CHEBI:57288; EC=2.3.3.21;
CC   -!- PATHWAY: Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-
CC       oxobutanoate from pyruvate: step 1/3.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SIMILARITY: Belongs to the alpha-IPM synthase/homocitrate synthase
CC       family.
XX
DR   Pfam; PF00682; HMGL-like; 1; trigger=no
DR   Pfam; PF08502; LeuA_dimer; 1; trigger=no
DR   NCBIfam; TIGR02090; LEU1_arch; 1; trigger=no
DR   PROSITE; PS00815; AIPM_HOMOCIT_SYNTH_1; 1; trigger=no
DR   PROSITE; PS00816; AIPM_HOMOCIT_SYNTH_2; 1; trigger=no
DR   PROSITE; PS50991; PYR_CT; 1; trigger=yes
XX
KW   Amino-acid biosynthesis
KW   Branched-chain amino acid biosynthesis
KW   Isoleucine biosynthesis
KW   Transferase
XX
GO   GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups
GO   GO:0009097; P:isoleucine biosynthetic process
XX
FT   None
XX
Size: 483-529;
Related: MF_01025; MF_00572;
Template: Q58787;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Difficulty to distinguish between LeuA, CimA and AksA subfamilies.
XX
# Revision 1.28 2023/06/01
//