AC   MF_01039;
DC   Protein; auto
TR   HAMAP; MF_01039; -; 1; level=0
XX
Names: PGAM_GpmA
XX
ID   GPMA
DE   RecName: Full=2,3-bisphosphoglycerate-dependent phosphoglycerate mutase;
DE            Short=BPG-dependent PGAM;
DE            Short=PGAM;
DE            Short=Phosphoglyceromutase;
DE            Short=dPGM;
DE            EC=5.4.2.11;
GN   Name=gpmA;
XX
CC   -!- FUNCTION: Catalyzes the interconversion of 2-phosphoglycerate and 3-
CC       phosphoglycerate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate;
CC         Xref=Rhea:RHEA:15901, ChEBI:CHEBI:58272, ChEBI:CHEBI:58289;
CC         EC=5.4.2.11;
CC   -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D-
CC       glyceraldehyde 3-phosphate: step 3/5.
case <OC:Pseudomonadota>
CC   -!- SUBUNIT: Homodimer.
end case
CC   -!- SIMILARITY: Belongs to the phosphoglycerate mutase family. BPG-
CC       dependent PGAM subfamily.
XX
DR   Pfam; PF00300; His_Phos_1; 1; trigger=no
DR   NCBIfam; TIGR01258; pgm_1; 1; trigger=no
DR   PROSITE; PS00175; PG_MUTASE; 1; trigger=no
XX
KW   Isomerase
KW   Glycolysis
KW   Gluconeogenesis
XX
GO   GO:0046538; F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity
GO   GO:0006094; P:gluconeogenesis
GO   GO:0006096; P:glycolytic process
XX
FT   From: GPMA_ECOLI (P62707)
FT   BINDING         10..17
FT                   /ligand="substrate"
FT   Optional; Condition: R-H-G-x-S-x(2)-[NK]
FT   BINDING         23..24
FT                   /ligand="substrate"
FT   Optional; Condition: [TS]-G
FT   BINDING         89..92
FT                   /ligand="substrate"
FT   Optional; Condition: E-[RK]-x-Y
FT   BINDING         116..117
FT                   /ligand="substrate"
FT   Optional; Condition: R-R
FT   BINDING         185..186
FT                   /ligand="substrate"
FT   Optional; Condition: G-N
FT   ACT_SITE        11
FT                   /note="Tele-phosphohistidine intermediate"
FT   Condition: H
FT   ACT_SITE        89
FT                   /note="Proton donor/acceptor"
FT   Condition: E
FT   BINDING         62
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         100
FT                   /ligand="substrate"
FT   Optional; Condition: K
FT   SITE            184
FT                   /note="Transition state stabilizer"
FT   Condition: H
XX
Size: 195-400;
Related: MF_01040;
Template: P62707; Q3JWH7; P9WIC9;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACC1, BACTN, GLOVI, LACJO, LACPL, LATSS, NITEU, NITMU
Plasmid: in RHIET
Comments: None
XX
# Revision 1.41 2023/06/01
//