AC   MF_01042;
DC   Protein; auto
TR   HAMAP; MF_01042; -; 1; level=0
XX
Names: SmrB
XX
ID   SMRB
DE   RecName: Full=Ribosome rescue factor SmrB;
DE            EC=3.1.-.-;
GN   Name=smrB;
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CC   -!- FUNCTION: Acts as a ribosome collision sensor. Detects stalled/collided
CC       disomes (pairs of ribosomes where the leading ribosome is stalled and a
CC       second ribosome has collided with it) and endonucleolytically cleaves
CC       mRNA at the 5' boundary of the stalled ribosome. Stalled/collided
CC       disomes form a new interface (primarily via the 30S subunits) that
CC       binds SmrB. Cleaved mRNA becomes available for tmRNA ligation, leading
CC       to ribosomal subunit dissociation and rescue of stalled ribosomes.
CC   -!- SUBUNIT: Associates with collided ribosomes, but not with correctly
CC       translating polysomes.
CC   -!- SIMILARITY: Belongs to the SmrB family.
XX
DR   Pfam; PF01713; Smr; 1; trigger=no
DR   PROSITE; PS50828; SMR; 1; trigger=yes
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KW   Endonuclease
KW   Hydrolase
KW   Nuclease
KW   RNA-binding
KW   rRNA-binding
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GO   GO:0019843; F:rRNA binding
GO   GO:0004521; F:RNA endonuclease activity
GO   GO:0072344; P:rescue of stalled ribosome
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FT   None
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Size: 167-200;
Related: None;
Template: P0A8B2;
Related: None;
Template: None;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Version: 17
# Last updated date: 2024-08-22
# Created date: 2005-02-28
//