AC   MF_01059;
DC   Protein; auto
TR   HAMAP; MF_01059; -; 1; level=0
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Names: Cyt_trehalase
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ID   TREF
DE   RecName: Full=Cytoplasmic trehalase;
DE            EC=3.2.1.28;
DE   AltName: Full=Alpha,alpha-trehalase;
DE   AltName: Full=Alpha,alpha-trehalose glucohydrolase;
GN   Name=treF;
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CC   -!- FUNCTION: Hydrolyzes trehalose to glucose. Could be involved, in cells
CC       returning to low osmolarity conditions, in the utilization of the
CC       accumulated cytoplasmic trehalose, which was synthesized in response to
CC       high osmolarity.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC         glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC         ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
CC   -!- PATHWAY: Glycan degradation; trehalose degradation; D-glucose from
CC       alpha,alpha-trehalose: step 1/1.
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
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DR   Pfam; PF01204; Trehalase; 1; trigger=no
DR   PRINTS; PR00744; GLHYDRLASE37; 1; trigger=no
DR   PROSITE; PS00927; TREHALASE_1; 1; trigger=no
DR   PROSITE; PS00928; TREHALASE_2; 1; trigger=no
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KW   Cytoplasm
KW   Hydrolase
KW   Glycosidase
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GO   GO:0004555; F:alpha,alpha-trehalase activity
GO   GO:0005993; P:trehalose catabolic process
GO   GO:0005737; C:cytoplasm
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FT   From: TREF_ECOLI (P62601)
FT   BINDING         175..176
FT                   /ligand="substrate"
FT   Optional; Condition: W-D
FT   BINDING         221..223
FT                   /ligand="substrate"
FT   Optional; Condition: R-S-Q
FT   BINDING         292..294
FT                   /ligand="substrate"
FT   Optional; Condition: R-D-E
FT   ACT_SITE        326
FT                   /note="Proton donor/acceptor"
FT   Condition: D
FT   ACT_SITE        509
FT                   /note="Proton donor/acceptor"
FT   Condition: E
FT   BINDING         168
FT                   /ligand="substrate"
FT   Optional; Condition: R
FT   BINDING         212
FT                   /ligand="substrate"
FT   Optional; Condition: N
FT   BINDING         324
FT                   /ligand="substrate"
FT   Optional; Condition: G
FT   BINDING         525
FT                   /ligand="substrate"
FT   Optional; Condition: E
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Size: 515-580;
Related: MF_01060;
Template: P62601;
Scope:
 Bacteria; Enterobacterales
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
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# Revision 1.23 2024/01/19
//