AC   MF_01060;
DC   Protein; auto
TR   HAMAP; MF_01060; -; 1; level=0
XX
Names: Peripl_trehalase
XX
ID   TREA
DE   RecName: Full=Periplasmic trehalase;
DE            EC=3.2.1.28;
DE   AltName: Full=Alpha,alpha-trehalase;
DE   AltName: Full=Alpha,alpha-trehalose glucohydrolase;
DE   Flags: Precursor;
GN   Name=treA;
XX
CC   -!- FUNCTION: Provides the cells with the ability to utilize trehalose at
CC       high osmolarity by splitting it into glucose molecules that can
CC       subsequently be taken up by the phosphotransferase-mediated uptake
CC       system.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha,alpha-trehalose + H2O = alpha-D-glucose + beta-D-
CC         glucose; Xref=Rhea:RHEA:32675, ChEBI:CHEBI:15377, ChEBI:CHEBI:15903,
CC         ChEBI:CHEBI:16551, ChEBI:CHEBI:17925; EC=3.2.1.28;
case <OC:Enterobacterales>
CC   -!- SUBUNIT: Monomer.
end case
CC   -!- SUBCELLULAR LOCATION: Periplasm.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 37 family.
XX
DR   Pfam; PF01204; Trehalase; 1; trigger=no
DR   PRINTS; PR00744; GLHYDRLASE37; 1; trigger=no
DR   PROSITE; PS00927; TREHALASE_1; 1; trigger=no
DR   PROSITE; PS00928; TREHALASE_2; 1; trigger=no
DR   General; Signal; -; 1; trigger=yes
XX
KW   Hydrolase
KW   Glycosidase
KW   Periplasm
KW   Signal
XX
GO   GO:0004555; F:alpha,alpha-trehalase activity
GO   GO:0005991; P:trehalose metabolic process
GO   GO:0042597; C:periplasmic space
XX
FT   From: TREA_ECOLI (P13482)
FT   BINDING         159..160
FT                   /ligand="substrate"
FT   Condition: W-D
FT   BINDING         205..207
FT                   /ligand="substrate"
FT   Condition: [RH]-S-Q
FT   BINDING         277..279
FT                   /ligand="substrate"
FT   Condition: R-[PQ]-E
FT   ACT_SITE        312
FT                   /note="Proton donor/acceptor"
FT   Condition: D
FT   ACT_SITE        496
FT                   /note="Proton donor/acceptor"
FT   Condition: E
FT   BINDING         152
FT                   /ligand="substrate"
FT   Condition: R
FT   BINDING         196
FT                   /ligand="substrate"
FT   Condition: N
FT   BINDING         310
FT                   /ligand="substrate"
FT   Condition: G
FT   BINDING         511
FT                   /ligand="substrate"
FT   Condition: E
XX
Size: 520-660;
Related: MF_01059;
Template: P13482;
Scope:
 Bacteria; Pseudomonadota
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: in RALN1
Comments: None
XX
# Revision 1.23 2023/11/28
//