AC   MF_01074;
DC   Protein; auto
TR   HAMAP; MF_01074; -; 1; level=0
XX
Names: LarC
XX
case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
ID   LARC
DE   RecName: Full=Pyridinium-3,5-bisthiocarboxylic acid mononucleotide nickel insertion protein;
DE            Short=P2TMN nickel insertion protein;
DE            EC=4.99.1.12;
DE   AltName: Full=Nickel-pincer cofactor biosynthesis protein LarC;
GN   Name=larC;
else
ID   Ynnn
DE   RecName: Full=Putative nickel insertion protein;
end case
XX
case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
CC   -!- FUNCTION: Involved in the biosynthesis of a nickel-pincer cofactor
CC       ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel
CC       delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide
CC       (P2TMN), to form the mature cofactor. Is thus probably required for the
CC       activation of nickel-pincer cofactor-dependent enzymes.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Ni(II)-pyridinium-3,5-bisthiocarboxylate mononucleotide =
CC         Ni(2+) + pyridinium-3,5-bisthiocarboxylate mononucleotide;
CC         Xref=Rhea:RHEA:54784, ChEBI:CHEBI:49786, ChEBI:CHEBI:137372,
CC         ChEBI:CHEBI:137373; EC=4.99.1.12;
end case
CC   -!- SIMILARITY: Belongs to the LarC family.
XX
DR   Pfam; PF01969; DUF111; 1; trigger=no
DR   NCBIfam; TIGR00299; TIGR00299; 1; trigger=no
XX
KW   Nickel
KW   Lyase
XX
GO   GO:0016151; F:nickel cation binding
GO   GO:0016829; F:lyase activity
case <OC:Bacillota> or <OC:Verrucomicrobiota> or <OC:Actinomycetota> or <OC:Thermotogae>
GO   GO:0051604; P:protein maturation
end case
XX
FT   None
XX
Size: 379-516;
Related: None;
Template: F9UST1;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Shorter N-terminal in ENTFA; not shown in alignment and not taken into account
 in size range
XX
# Revision 1.26 2023/06/01
//