AC   MF_01075;
DC   Protein; auto
TR   HAMAP; MF_01075; -; 1; level=0
XX
Names: NhaP2
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ID   NHAP2
DE   RecName: Full=K(+)/H(+) antiporter NhaP2;
DE   AltName: Full=Potassium/proton antiporter NhaP2;
GN   Name=nhaP2;
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CC   -!- FUNCTION: K(+)/H(+) antiporter that extrudes potassium in exchange for
CC       external protons and maintains the internal concentration of potassium
CC       under toxic levels.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+)(out) + K(+)(in) = H(+)(in) + K(+)(out);
CC         Xref=Rhea:RHEA:29467, ChEBI:CHEBI:15378, ChEBI:CHEBI:29103;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:29468;
case not defined <Property:Membrane> or <Property:Membrane=1>
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
else case <Property:Membrane=2>
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane; Multi-pass membrane protein.
end case
CC   -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 1 (CPA1)
CC       transporter (TC 2.A.36) family. NhaP2 subfamily.
XX
DR   Pfam; PF03471; CorC_HlyC; 1; trigger=no
DR   Pfam; PF00999; Na_H_Exchanger; 1; trigger=no
DR   Pfam; PF02080; TrkA_C; 1; trigger=no
DR   PROSITE; PS51202; RCK_C; 1; trigger=yes
DR   General; Transmembrane; -; 10-13; trigger=yes
XX
KW   Antiport
case defined <Property:Membrane> and <Property:Membrane=2>
KW   Cell inner membrane
end case
KW   Cell membrane
KW   Ion transport
KW   Membrane
KW   Potassium
KW   Potassium transport
KW   Transmembrane
KW   Transmembrane helix
KW   Transport
XX
GO   GO:0015386; F:potassium:proton antiporter activity
GO   GO:0015079; F:potassium ion transmembrane transporter activity
GO   GO:0071805; P:potassium ion transmembrane transport
GO   GO:0005886; C:plasma membrane
XX
FT   None
XX
Size: 538-640;
Related: None;
Template: A5F4U3; Q87KV8; P76007;
Scope:
 Bacteria; Gammaproteobacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.36 2022/09/29
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