AC   MF_01080;
DC   Protein; auto
TR   HAMAP; MF_01080; -; 1; level=0
XX
Names: TruB_bact
XX
ID   TRUB
DE   RecName: Full=tRNA pseudouridine synthase B;
DE            EC=5.4.99.25;
DE   AltName: Full=tRNA pseudouridine(55) synthase;
DE            Short=Psi55 synthase;
DE   AltName: Full=tRNA pseudouridylate synthase;
DE   AltName: Full=tRNA-uridine isomerase;
GN   Name=truB;
XX
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-55 in
CC       the psi GC loop of transfer RNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA;
CC         Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.25;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family. Type 1
CC       subfamily.
XX
DR   Pfam; PF01509; TruB_N; 1; trigger=no
DR   Pfam; PF01472; PUA; 1; trigger=no
DR   NCBIfam; TIGR00431; TruB; 1; trigger=no
DR   PROSITE; PS50890; PUA; 0-1; trigger=yes
XX
KW   Isomerase
KW   tRNA processing
XX
GO   GO:0009982; F:pseudouridine synthase activity
GO   GO:0031119; P:tRNA pseudouridine synthesis
XX
FT   From: TRUB_ECOLI (P60340)
FT   ACT_SITE        48
FT                   /note="Nucleophile"
FT   Condition: D
case <OC:Enterobacterales>
FT   BINDING         43
FT                   /ligand="substrate"
FT   Condition: H
FT   BINDING         76
FT                   /ligand="substrate"
FT   Condition: Y
FT   BINDING         179
FT                   /ligand="substrate"
FT   Condition: Y
FT   BINDING         200
FT                   /ligand="substrate"
FT   Condition: L
end case
XX
Size: 218-387;
Related: MF_01081;
Template: P60340; P9WHP7; Q9WZW0;
Scope:
 Bacteria
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.27 2023/06/01
//