AC   MF_01081;
DC   Protein; auto
TR   HAMAP; MF_01081; -; 1; level=0
XX
Names: TruB_arch
XX
ID   TRUB
DE   RecName: Full=Probable tRNA pseudouridine synthase B;
DE            EC=5.4.99.25;
DE   AltName: Full=tRNA pseudouridine(55) synthase;
DE            Short=Psi55 synthase;
DE   AltName: Full=tRNA pseudouridylate synthase;
DE   AltName: Full=tRNA-uridine isomerase;
GN   Name=truB;
XX
CC   -!- FUNCTION: Could be responsible for synthesis of pseudouridine from
CC       uracil-55 in the psi GC loop of transfer RNAs.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(55) in tRNA = pseudouridine(55) in tRNA;
CC         Xref=Rhea:RHEA:42532, Rhea:RHEA-COMP:10101, Rhea:RHEA-COMP:10102,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.25;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruB family. Type 2
CC       subfamily.
XX
DR   Pfam; PF01472; PUA; 1; trigger=no
DR   Pfam; PF01509; TruB_N; 1; trigger=no
DR   NCBIfam; TIGR00425; CBF5; 1; trigger=no
DR   NCBIfam; TIGR00451; Unchar_dom_2; 1; trigger=no
DR   NCBIfam; TIGR00431; TruB; 1; trigger=no
DR   PROSITE; PS50890; PUA; 0-1; trigger=yes
XX
KW   Isomerase
KW   tRNA processing
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GO   GO:0009982; F:pseudouridine synthase activity
GO   GO:0031119; P:tRNA pseudouridine synthesis
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FT   From: TRUB_ARCFU (O30001)
FT   ACT_SITE        69
FT                   /note="Nucleophile"
FT   Condition: D
XX
Size: 301-365;
Related: MF_01080;
Template: P60340; P9WHP7; Q9WZW0;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: Active site is not conserved in AERPE.
 Shorter N-terminal in SACS2; not shown in alignment and not taken into
 account in size range.
XX
# Revision 1.24 2023/06/01
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