AC   MF_01082;
DC   Protein; auto
TR   HAMAP; MF_01082; -; 1; level=0
XX
Names: TruD
XX
ID   TRUD
case <OC:Bacteria>
DE   RecName: Full=tRNA pseudouridine synthase D;
DE            EC=5.4.99.27;
DE   AltName: Full=tRNA pseudouridine(13) synthase;
DE   AltName: Full=tRNA pseudouridylate synthase D;
DE   AltName: Full=tRNA-uridine isomerase D;
end case
case <OC:Archaea>
DE   RecName: Full=Probable tRNA pseudouridine synthase D;
DE            EC=5.4.99.27;
DE   AltName: Full=tRNA pseudouridine(13) synthase;
DE   AltName: Full=tRNA pseudouridylate synthase D;
DE   AltName: Full=tRNA-uridine isomerase D;
end case
GN   Name=truD;
XX
case <OC:Bacteria>
CC   -!- FUNCTION: Responsible for synthesis of pseudouridine from uracil-13 in
CC       transfer RNAs.
end case
case <OC:Archaea>
CC   -!- FUNCTION: Could be responsible for synthesis of pseudouridine from
CC       uracil-13 in transfer RNAs.
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=uridine(13) in tRNA = pseudouridine(13) in tRNA;
CC         Xref=Rhea:RHEA:42540, Rhea:RHEA-COMP:10105, Rhea:RHEA-COMP:10106,
CC         ChEBI:CHEBI:65314, ChEBI:CHEBI:65315; EC=5.4.99.27;
CC   -!- SIMILARITY: Belongs to the pseudouridine synthase TruD family.
XX
DR   Pfam; PF01142; TruD; 1; trigger=no
DR   NCBIfam; TIGR00094; TRNA_TruD_broad; 1; trigger=no
DR   PROSITE; PS50984; TRUD; 1; trigger=yes
DR   PROSITE; PS01268; UPF0024; 1; trigger=no
XX
KW   Isomerase
KW   tRNA processing
XX
GO   GO:0009982; F:pseudouridine synthase activity
GO   GO:0031119; P:tRNA pseudouridine synthesis
XX
FT   From: TRUD_ECOLI (Q57261)
FT   ACT_SITE        80
FT                   /note="Nucleophile"
FT   Condition: D
case <OC:Enterobacterales>
FT   BINDING         27
FT                   /ligand="substrate"
FT   Condition: F
FT   BINDING         129
FT                   /ligand="substrate"
FT   Condition: N
FT   BINDING         329
FT                   /ligand="substrate"
FT   Condition: F
end case
XX
Size: 335-460;
Related: None;
Template: Q57261;
Scope:
 Bacteria
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in METJA, METMP
Plasmid: None
Comments: None
XX
# Revision 1.29 2023/06/01
//