AC   MF_01083;
DC   Protein; auto
TR   HAMAP; MF_01083; -; 1; level=0
XX
Names: glutarate_hydroxylase
XX
ID   GLAH
DE   RecName: Full=Glutarate 2-hydroxylase;
DE            Short=G-2-H;
DE            EC=1.14.11.64;
GN   Name=glaH;
XX
CC   -!- FUNCTION: Acts as an alpha-ketoglutarate-dependent dioxygenase
CC       catalyzing hydroxylation of glutarate (GA) to L-2-hydroxyglutarate
CC       (L2HG). Functions in a L-lysine degradation pathway that proceeds via
CC       cadaverine, glutarate and L-2-hydroxyglutarate.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=2-oxoglutarate + glutarate + O2 = (S)-2-hydroxyglutarate + CO2
CC         + succinate; Xref=Rhea:RHEA:13821, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16526, ChEBI:CHEBI:16782, ChEBI:CHEBI:16810,
CC         ChEBI:CHEBI:30031, ChEBI:CHEBI:30921; EC=1.14.11.64;
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:13822;
case <FTGroup:1>
CC   -!- COFACTOR:
CC       Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
CC       Note=Binds 1 Fe(2+) ion per subunit
end case
CC   -!- PATHWAY: Amino-acid degradation.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- SIMILARITY: Belongs to the glutarate hydroxylase family.
XX
DR   Pfam; PF08943; CsiD; 1; trigger=no
XX
KW   Dioxygenase
KW   Oxidoreductase
case <FTGroup:1>
KW   Metal-binding
KW   Iron
end case
XX
GO   GO:0050498; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated
GO   GO:0019477; P:L-lysine catabolic process
case <FTGroup:1>
GO   GO:0008198; F:ferrous iron binding
end case
XX
FT   From: GLAH_ECOLI (P76621)
FT   BINDING         160
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Group: 1; Condition: H
FT   BINDING         162
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Group: 1; Condition: D
FT   BINDING         292
FT                   /ligand="Fe cation"
FT                   /ligand_id="ChEBI:CHEBI:24875"
FT   Group: 1; Condition: H
XX
Size: 310-325;
Related: None;
Template: P76621;
Scope:
 Bacteria; Enterobacterales
 Bacteria; Pseudomonadaceae
Fusion:
 Nter: None
 Cter: None
Duplicate: None
Plasmid: None
Comments: None
XX
# Revision 1.19 2022/11/19
//