AC   MF_01124;
DC   Protein; auto
TR   HAMAP; MF_01124; -; 1; level=0
XX
Names: MecA
XX
ID   MECA
DE   RecName: Full=Adapter protein MecA;
GN   Name=mecA;
XX
case <OC:Bacillaceae>
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis. Acts negatively in the development of competence by
CC       binding ComK and recruiting it to the ClpCP protease. When
CC       overexpressed, inhibits sporulation. Also involved in Spx degradation
CC       by ClpC.
else
CC   -!- FUNCTION: Enables the recognition and targeting of unfolded and
CC       aggregated proteins to the ClpC protease or to other proteins involved
CC       in proteolysis.
end case
CC   -!- SUBUNIT: Homodimer.
case <OC:Bacillaceae>
CC   -!- DOMAIN: The N-terminal domain has binding sites for ComK and probably
CC       for unfolded/aggregated proteins; the C-terminal domain interacts with
CC       ClpC.
else
CC   -!- DOMAIN: The N-terminal domain probably binds unfolded/aggregated
CC       proteins; the C-terminal domain interacts with ClpC.
end case
CC   -!- SIMILARITY: Belongs to the MecA family.
XX
DR   Pfam; PF05389; MecA; 1; trigger=no
DR   PIRSF; PIRSF029008; MecA; 1; trigger=no
XX
case <OC:Bacillaceae>
KW   Competence
KW   Sporulation
end case
XX
GO   GO:0030674; F:protein-macromolecule adaptor activity
case <OC:Bacillaceae>
GO   GO:0045808; P:negative regulation of establishment of competence for transformation
GO   GO:0042174; P:negative regulation of sporulation resulting in formation of a cellular spore
end case
XX
FT   None
XX
Size: 192-253;
Related: None;
Template: P37958;
Scope:
 Bacteria; Bacillota
Fusion:
 Nter: None
 Cter: None
Duplicate: in BACAN, BACCR, HALH5, BACSU
Plasmid: None
Comments: None
XX
# Revision 1.15 2023/01/17
//