AC   MF_01136;
DC   Protein; auto
TR   HAMAP; MF_01136; -; 1; level=0
XX
Names: CdhE
XX
ID   ACDG
DE   RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit gamma;
DE            Short=ACDS complex subunit gamma;
DE            EC=2.1.1.245;
DE   AltName: Full=5-methyltetrahydrosarcinapterin:corrinoid/iron-sulfur protein Co-methyltransferase;
DE   AltName: Full=ACDS complex methyltransferase;
DE   AltName: Full=Corrinoid/iron-sulfur component large subunit;
GN   Name=cdhE;
XX
case <OC:Methanosarcinaceae>
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC       acetyl-CoA, allowing growth on acetate as sole source of carbon and
CC       energy.
end case
case not <OC:Methanosarcinaceae>
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC       acetyl-CoA, allowing autotrophic growth from CO(2).
end case
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5,6,7,8-tetrahydrosarcinapterin + methyl-Co(III)-[corrinoid
CC         Fe-S protein] = 5-methyltetrahydrosarcinapterin + Co(I)-[corrinoid
CC         Fe-S protein] + H(+); Xref=Rhea:RHEA:45196, Rhea:RHEA-COMP:11110,
CC         Rhea:RHEA-COMP:11111, ChEBI:CHEBI:15378, ChEBI:CHEBI:59924,
CC         ChEBI:CHEBI:64267, ChEBI:CHEBI:85033, ChEBI:CHEBI:85035;
CC         EC=2.1.1.245;
CC   -!- COFACTOR:
CC       Name=corrinoid; Xref=ChEBI:CHEBI:33913;
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC       Note=Binds 1 [4Fe-4S] cluster.;
case <OC:Methanosarcinaceae>
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from acetate.
end case
CC   -!- SUBUNIT: Heterodimer of delta and gamma chains. The ACDS complex is
CC       made up of alpha, epsilon, beta, gamma and delta chains with a probable
CC       stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).
XX
DR   Pfam; PF03599; CdhD; 1; trigger=no
DR   Pfam; PF04060; FeS; 1; trigger=no
DR   PROSITE; PS51656; 4FE4S; 1; trigger=yes
DR   PROSITE; PS00198; 4FE4S_FER_1; 1; trigger=no
XX
case <OC:Methanosarcinaceae>
KW   Methanogenesis
end case
KW   Transferase
KW   Methyltransferase
case <FTGroup:1>
KW   Metal-binding
KW   Cobalt
KW   Iron
KW   Iron-sulfur
KW   4Fe-4S
end case
XX
case <FTGroup:1>
GO   GO:0005506; F:iron ion binding
end case
GO   GO:0008168; F:methyltransferase activity
case <OC:Methanosarcinaceae>
GO   GO:0019385; P:methanogenesis, from acetate
end case
XX
FT   From: ACDG1_METTE (Q50539)
FT   BINDING         18
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         21
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         26
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
FT   BINDING         43
FT                   /ligand="[4Fe-4S] cluster"
FT                   /ligand_id="ChEBI:CHEBI:49883"
FT   Group: 1; Condition: C
XX
Size: 458-488;
Related: None;
Template: Q50539;
Scope:
 Archaea
Fusion:
 Nter: None
 Cter: None
Duplicate: in METMA, METTE
Plasmid: None
Comments: None
XX
# Revision 1.28 2022/11/19
//