AC MF_01138; DC Protein; auto TR HAMAP; MF_01138; -; 1; level=0 XX Names: CdhC XX ID ACDB DE RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit beta; DE Short=ACDS complex subunit beta; DE EC=2.3.1.169; DE AltName: Full=ACDS complex acyltransferase; GN Name=cdhC; XX case CC -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of CC acetyl-CoA, allowing growth on acetate as sole source of carbon and CC energy. The alpha-epsilon complex generates CO from CO(2), while the CC beta subunit (this protein) combines the CO with CoA and a methyl group CC to form acetyl-CoA. The methyl group, which is incorporated into CC acetyl-CoA, is transferred to the beta subunit by a corrinoid iron- CC sulfur protein (the gamma-delta complex). end case case not CC -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of CC acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon CC complex generates CO from CO(2), while the beta subunit (this protein) CC combines the CO with CoA and a methyl group to form acetyl-CoA. The CC methyl group, which is incorporated into acetyl-CoA, is transferred to CC the beta subunit by a corrinoid iron-sulfur protein (the gamma-delta CC complex). end case CC -!- CATALYTIC ACTIVITY: CC Reaction=acetyl-CoA + Co(I)-[corrinoid Fe-S protein] + H(+) = CO + CoA CC + methyl-Co(III)-[corrinoid Fe-S protein]; Xref=Rhea:RHEA:45212, CC Rhea:RHEA-COMP:11110, Rhea:RHEA-COMP:11111, ChEBI:CHEBI:15378, CC ChEBI:CHEBI:17245, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, CC ChEBI:CHEBI:85033, ChEBI:CHEBI:85035; EC=2.3.1.169; CC -!- COFACTOR: CC Name=[Ni-Fe-S] cluster; Xref=ChEBI:CHEBI:60400; CC Note=Binds 1 [Ni-Fe-S] cluster.; case CC -!- PATHWAY: One-carbon metabolism; methanogenesis from acetate. end case CC -!- SUBUNIT: Monomer. The ACDS complex is made up of alpha, epsilon, beta, CC gamma and delta chains with a probable stoichiometry of CC (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8). CC -!- SIMILARITY: Belongs to the CdhC family. XX DR Pfam; PF03598; CdhC; 1; trigger=no DR NCBIfam; TIGR00316; CdhC; 1; trigger=no XX case KW Methanogenesis end case KW Transferase KW Acyltransferase case KW Metal-binding KW Iron KW Nickel KW Iron-sulfur end case XX GO GO:0016407; F:acetyltransferase activity case GO GO:0005506; F:iron ion binding GO GO:0016151; F:nickel cation binding end case case GO GO:0019385; P:methanogenesis, from acetate end case XX FT From: ACDB2_METTE (Q9V2Z4) FT BINDING 189 FT /ligand="[Ni-Fe-S] cluster" FT /ligand_id="ChEBI:CHEBI:60400" FT Group: 1; Condition: C FT BINDING 192 FT /ligand="[Ni-Fe-S] cluster" FT /ligand_id="ChEBI:CHEBI:60400" FT Group: 1; Condition: C FT BINDING 278 FT /ligand="[Ni-Fe-S] cluster" FT /ligand_id="ChEBI:CHEBI:60400" FT Group: 1; Condition: C FT BINDING 280 FT /ligand="[Ni-Fe-S] cluster" FT /ligand_id="ChEBI:CHEBI:60400" FT Group: 1; Condition: C XX Size: 460-524; Related: None; Template: Q9V2Z4; Scope: Archaea Fusion: Nter: None Cter: None Duplicate: in METAC, METMA, METTE Plasmid: None Comments: None XX # Revision 1.24 2023/06/01 //